Lecture

Protein Homeostasis Networks: Promoting Healthy Ageing

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Description

This lecture by the instructor explores the importance of maintaining protein homeostasis for long-term health, focusing on the manipulation of protein networks to promote healthy ageing. The talk covers topics such as the impact of stress, mutations, and ageing on protein folding, the use of C. elegans as a model for studying proteostasis collapse, and the role of mitochondria in regulating proteostasis. The lecture also delves into how mild mitochondrial stress can extend lifespan and suppress proteostasis collapse. Furthermore, it discusses the activation of a mitochondria-to-HSF1 stress response and the involvement of the PP2A complex in safeguarding the proteome. Overall, the lecture highlights the potential of manipulating protein homeostasis networks to enhance healthy ageing.

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Life extension

Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition.

Outline of life extension

Index of life extension-related articles The following outline is provided as an overview of and topical guide to life extension: Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology.

Maximum life span

Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity. Most living species have an upper limit on the number of times somatic cells not expressing telomerase can divide.

Index of topics related to life extension

Following is a list of topics related to life extension: NOTOC ACE inhibitor Actuarial escape velocity Adenosine triphosphate (ATP) Advanced Cell Technology Corporation Aerobic exercise Age-adjusted life expectancy Ageless Age-Related Eye Disease Study Age-Related Macular Degeneration Aging Aging and memory Aging-associated diseases Aging brain Aging population Alcor Life Extension Foundation Alternative medicine American Aging Association American Academy of Anti-Aging Medicine (A4M) Amyloid Amyloid pl

Timeline of aging research

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