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This lecture introduces the concepts and definitions of science and technology for Disaster Risk Reduction (DRR). It covers the types of science, such as social, life, and physical sciences, and the importance of integrating different sciences for DRR. The lecture also explains the various types of technologies, including appropriate and frugal technologies, and provides examples of science and technology applications for DRR, such as mapping technologies and health technologies. The relevance of science and technology in reducing the consequences of disasters, aiding in emergency relief, and promoting sustainable development is discussed, emphasizing the need for interdisciplinary approaches to address vulnerability and communicate risks.