Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Blood Glucose Regulation

In course

ME-323: Chemical process control

Provide the students with basic notions and tools for the modeling and analysis of dynamic systems. Show them how to design controllers and analyze the performance of controlled systems. ...

Description

This lecture explains how the body regulates blood glucose levels through the release of insulin and glucagon, the conversion of glucose to glycogen, and the role of the pancreas, liver, and skeletal muscles in maintaining glucose balance. The instructor also discusses the concept of set points, controllers, actuators, and sensors in the context of body temperature and blood glucose regulation, emphasizing the common principles underlying control systems in different physiological processes.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Instructor

Ljubisa Miskovic

Ljubisa Miskovic earned his Ph.D. degree in Automatic Control from the Swiss Federal Institute of Technology (EPFL) under the co-supervision of Dominique Bonvin and Alireza Karimi, in 2006. He pursued his postdoctoral studies at the Centre for Systems Engineering and Applied Mechanics, Universite Catholique de Louvain with Michel Gevers before moving to the laboratory of Vassily Hatzimanikatis at the EPFL. In 2010, he became a research scientist. His research interests include systems biology, metabolic engineering, synthetic biology, data-driven control design, system identification, stochastic processes and estimation theory.

Official source

Ontological neighbourhood

Health sciences

Endocrinology: Topics in endocrinology

Related concepts (20)

Blood sugar level

The blood sugar level, blood sugar concentration, blood glucose level, or glycemia, is the measure of glucose concentrated in the blood. The body tightly regulates blood glucose levels as a part of metabolic homeostasis. For a 70 kg (154 lb) human, approximately four grams of dissolved glucose (also called "blood glucose") is maintained in the blood plasma at all times.

Insulin

Insulin (ˈɪn.sjʊ.lɪn, from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both.

Blood glucose monitoring

Blood glucose monitoring is the use of a glucose meter for testing the concentration of glucose in the blood (glycemia). Particularly important in diabetes management, a blood glucose test is typically performed by piercing the skin (typically, via fingerstick) to draw blood, then applying the blood to a chemically active disposable 'test-strip'. The other main option is continuous glucose monitoring (CGM). Different manufacturers use different technology, but most systems measure an electrical characteristic and use this to determine the glucose level in the blood.

Insulin analog

An insulin analog (also called an insulin analogue) is any of several types of medical insulin that are altered forms of the hormone insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of controlling blood glucose levels in diabetes. Through genetic engineering of the underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics.

Insulin pump

An insulin pump is a medical device used for the administration of insulin in the treatment of diabetes mellitus, also known as continuous subcutaneous insulin therapy. The device configuration may vary depending on design. A traditional pump includes: the pump (including controls, processing module, and batteries) a disposable reservoir for insulin (inside the pump) a disposable infusion set, including a cannula for subcutaneous insertion (under the skin) and a tubing system to connect the insulin reservoir to the cannula.

Related lectures (31)

Metabolism 1: General Overview

Provides an overview of carbohydrate, lipid, and protein metabolism, insulin function, and hormonal control of food intake.

Metabolism 1: General Overview

Covers carbohydrate, lipid, and protein metabolism, insulin-receptor interaction, fat storage, and blood glucose control.

Metabolism and Hormones

Explores tissue-specific metabolism, hormone regulation, and enzyme cascades in glucose and lipid metabolism.