Lecture

Electrochemical Biosensors

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Description

This lecture covers the principles of electrochemical biosensors, focusing on the working current emerging from the working electrode, the importance of feedback resistance, and the role of operational amplifiers in differential amplifiers. The instructor explains how enzymes like oxidases and cytochromes play a crucial role in detecting specific molecules, such as glucose and cholesterol, in electrochemical cells. The lecture also delves into the challenges of measuring ions and pH levels in biosensing devices, emphasizing the significance of sensitivity and detection limits.

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Related concepts (28)

Operational amplifier

An operational amplifier (often op amp or opamp) is a DC-coupled high-gain electronic voltage amplifier with a differential input and, usually, a single-ended output. In this configuration, an op amp produces an output potential (relative to circuit ground) that is typically 100,000 times larger than the potential difference between its input terminals. The operational amplifier traces its origin and name to analog computers, where they were used to perform mathematical operations in linear, non-linear, and frequency-dependent circuits.

Differential amplifier

A differential amplifier is a type of electronic amplifier that amplifies the difference between two input voltages but suppresses any voltage common to the two inputs. It is an analog circuit with two inputs and and one output , in which the output is ideally proportional to the difference between the two voltages: where is the gain of the amplifier. Single amplifiers are usually implemented by either adding the appropriate feedback resistors to a standard op-amp, or with a dedicated integrated circuit containing internal feedback resistors.

Instrumentation amplifier

An instrumentation amplifier (sometimes shorthanded as in-amp or InAmp) is a type of differential amplifier that has been outfitted with input buffer amplifiers, which eliminate the need for input impedance matching and thus make the amplifier particularly suitable for use in measurement and test equipment. Additional characteristics include very low DC offset, low drift, low noise, very high open-loop gain, very high common-mode rejection ratio, and very high input impedances.

Amplifier

An amplifier, electronic amplifier or (informally) amp is an electronic device that can increase the magnitude of a signal (a time-varying voltage or current). It is a two-port electronic circuit that uses electric power from a power supply to increase the amplitude (magnitude of the voltage or current) of a signal applied to its input terminals, producing a proportionally greater amplitude signal at its output. The amount of amplification provided by an amplifier is measured by its gain: the ratio of output voltage, current, or power to input.

Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction.

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