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This lecture covers the principles of pulse oximetry, focusing on the optical sensors used to measure oxygen saturation in tissue. Topics include the absorption coefficients of hemoglobin, the expression of SO₂, and the normalization and calibration techniques. The instructor explains the conditioning process involving two wavelengths, the synchronous detection method, and provides an example of a wireless pulse oximeter model. Emphasis is placed on the design of pulse oximeters and the practical aspects of using these devices in medical settings.