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This lecture explores the concepts of Immersive Virtual Reality and Telepresence, focusing on their cognitive foundations. It delves into the quantifiable aspects of VR technology, such as immersion and presence, and their impact on perception and action. The discussion extends to the clinical applications of Virtual Reality, including Cognitive Behavioral Therapy and pain distraction techniques. The lecture also covers topics like Virtual Reality Exposure Therapy and the Rubber Hand Illusion, shedding light on the intricate relationship between sensory input and self-awareness in virtual environments.