Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Cancer Vaccines: Immune Activation

In course

BIO-310: Immunology

Ce cours décrit le fonctionnement du système immunitaire humain et les bases immunologiques de la vaccination, de la transplantation, de l'immunothérapie, et de l'allergie. Il présente aussi le rôle des cellules souches dans la formation des tissus, notamm ...

Description

This lecture covers the activation of naive CD8+ T cells into cytotoxic T lymphocytes, the generation of CD8+ memory T cells, and the stimulation of anergic CD8+ T cells in the context of cancer vaccines. It discusses the challenges of solid tumors, the types of cancer vaccines, and the use of dendritic cell therapies, including the 2011 Nobel Prize-winning approach.

In MOOC

Introduction to immunology (part 2)

Instructors (2)

Bruno Lemaitre

David Michael Suter

Official source

Quiz

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (19)

T cell

T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells.

T helper cell

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils.

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

Naive T cell

In immunology, a naive T cell (Th0 cell) is a T cell that has differentiated in the thymus, and successfully undergone the positive and negative processes of central selection in the thymus. Among these are the naive forms of helper T cells (CD4+) and cytotoxic T cells (CD8+). Any naive T cell is considered immature and, unlike activated or memory T cells, has not encountered its cognate antigen within the periphery. After this encounter, the naive T cell is considered a mature T cell.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Related lectures (35)

An Overview of Vaccines

Covers precision tumor recognition, challenges in T cell therapy, vaccination impact, history, types, and examples of vaccines, immune response, and COVID-19 vaccine types.

Immune System Defense

Explores the immune system's defense mechanisms, including epithelial barriers, innate immunity, adaptive immunity, B and T cells, antibodies, and immunological memory.

Immune System: T Cells and Antigen Presentation

Explores T cells, antigen presentation, cytotoxicity, MHC proteins, apoptosis, and vaccine principles.

Design of Immunogenic Vaccines

Explores the challenges and triumphs in designing immunogenic vaccines, focusing on antigens, adjuvants, and the delivery strategies for effective vaccination.

Immunoengineering: Introduction