Lecture

Precision Oncology: Predictive Biomarkers

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In course

HUM-388: Personalized health: biomedical & social challenge

La médecine personnalisée, préventive, prédictive et participative bouleverse les connaissances médicales établies, ainsi que les configurations sociales et politiques de la médecine. Ce cours analyse ces processus à travers une approche interdisciplinaire ...

Description

This lecture introduces the field of precision oncology, focusing on the opportunities and challenges in utilizing genomics, immunotherapies, and digital tools to enhance cancer diagnosis, prognosis, and therapy. The presentation covers the principles of precision oncology, the transformation of personalized oncology through big data analysis, the applications of Next-Generation Sequencing (NGS) in personalized oncology, clonal heterogeneity, immune response mechanisms, and the personalization of immuno-oncology. It also discusses the challenges and opportunities in personalized oncology, the use of natural language processing (NLP) in oncology, and the development of explainable AI for digital pathology.

Instructor

Luca Chiapperino

Expertise Social Studies of Science; Science and Technology Studies; Public Health Ethics; Applied Philosophy; Sustainability Transitions Teaching & PhD Courses Health A: Innovation, Equity, Sustainability HUM-125(a) The course provides an interdisciplinary examination of key global health challenges, focusing on biomedical innovations, pharmaceuticals, sustainability, mental health, and health policies. It offer a critical skillset to engineering students approaching these complex health ch

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Related concepts (32)

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Data analysis

Data analysis is the process of inspecting, cleansing, transforming, and modeling data with the goal of discovering useful information, informing conclusions, and supporting decision-making. Data analysis has multiple facets and approaches, encompassing diverse techniques under a variety of names, and is used in different business, science, and social science domains. In today's business world, data analysis plays a role in making decisions more scientific and helping businesses operate more effectively.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Pathology

Pathology is the study of the causes and effects of disease or injury. The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples.

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