Lecture

Metabolism and Proteostasis Evolution

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Description

This lecture by Kausik Chakraborty explores the connection between metabolism and proteostasis through evolution, focusing on the intracellular homeostasis of protein biogenesis, the study of proteostasis capacity, and the role of mutational buffering in protein evolution. The lecture delves into how different osmolytes alter folding pathways and structures, the impact of genetic alterations in cellular metabolism on mutational buffering capacity, and the role of metabolites in altering protein folding. It also discusses the evolution of osmotolerant strains, the regulation of mutational buffering by the cellular chemical milieu, and the convergence of metabolite perturbation. The lecture concludes by highlighting the importance of small-molecule-dependent folding in reinforcing proteostasis.

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Related concepts (32)

Metabolism

Metabolism (məˈtæbəlɪzəm, from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments.

Evolution

In biology, evolution is the change in heritable characteristics of biological populations over successive generations. Evolution occurs when evolutionary processes such as natural selection (including sexual selection) and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation.

Objections to evolution

Objections to evolution have been raised since evolutionary ideas came to prominence in the 19th century. When Charles Darwin published his 1859 book On the Origin of Species, his theory of evolution (the idea that species arose through descent with modification from a single common ancestor in a process driven by natural selection) initially met opposition from scientists with different theories, but eventually came to receive overwhelming acceptance in the scientific community.

Theistic evolution

Theistic evolution (also known as theistic evolutionism or God-guided evolution) is a view that God acts and creates through laws of nature. It posits that the concept of God is compatible with the findings of modern science, including evolution. Theistic evolution is not in itself a scientific theory, but includes a range of views about how science relates to religious beliefs and the extent to which God intervenes. It rejects the strict creationist doctrines of special creation, but can include beliefs such as creation of the human soul.

Molecular evolution

Molecular evolution is the process of change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes. Major topics in molecular evolution concern the rates and impacts of single nucleotide changes, neutral evolution vs. natural selection, origins of new genes, the genetic nature of complex traits, the genetic basis of speciation, the evolution of development, and ways that evolutionary forces influence genomic and phenotypic changes.

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