Multiple sequence alignmentMultiple sequence alignment (MSA) may refer to the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutionary relationship by which they share a linkage and are descended from a common ancestor. From the resulting MSA, sequence homology can be inferred and phylogenetic analysis can be conducted to assess the sequences' shared evolutionary origins.
Sequence alignmentIn bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. Aligned sequences of nucleotide or amino acid residues are typically represented as rows within a matrix. Gaps are inserted between the residues so that identical or similar characters are aligned in successive columns.
Sine and cosineIn mathematics, sine and cosine are trigonometric functions of an angle. The sine and cosine of an acute angle are defined in the context of a right triangle: for the specified angle, its sine is the ratio of the length of the side that is opposite that angle to the length of the longest side of the triangle (the hypotenuse), and the cosine is the ratio of the length of the adjacent leg to that of the hypotenuse. For an angle , the sine and cosine functions are denoted simply as and .
Structural alignmentStructural alignment attempts to establish homology between two or more polymer structures based on their shape and three-dimensional conformation. This process is usually applied to protein tertiary structures but can also be used for large RNA molecules. In contrast to simple structural superposition, where at least some equivalent residues of the two structures are known, structural alignment requires no a priori knowledge of equivalent positions.
Law of cosinesIn trigonometry, the law of cosines (also known as the cosine formula or cosine rule) relates the lengths of the sides of a triangle to the cosine of one of its angles. For a triangle with sides and opposite respective angles and (see Fig. 1), the law of cosines states: The law of cosines generalizes the Pythagorean theorem, which holds only for right triangles: if is a right angle then and the law of cosines reduces to The law of cosines is useful for solving a triangle when all three sides or two sides and their included angle are given.
Exact trigonometric valuesIn mathematics, the values of the trigonometric functions can be expressed approximately, as in , or exactly, as in . While trigonometric tables contain many approximate values, the exact values for certain angles can be expressed by a combination of arithmetic operations and square roots. The trigonometric functions of angles that are multiples of 15°, 18°, or 22.5° have simple algebraic values. These values are listed in the following table for angles from 0° to 90°.
Special right triangleA special right triangle is a right triangle with some regular feature that makes calculations on the triangle easier, or for which simple formulas exist. For example, a right triangle may have angles that form simple relationships, such as 45°–45°–90°. This is called an "angle-based" right triangle. A "side-based" right triangle is one in which the lengths of the sides form ratios of whole numbers, such as 3 : 4 : 5, or of other special numbers such as the golden ratio.
SinIn a religious context, 'sin' is a transgression against divine law or a law of God. Each culture has its own interpretation of what it means to commit a sin. While sins are generally considered actions, any thought, word, or act considered immoral, selfish, shameful, harmful, or alienating might be termed "sinful".
Euler's formulaEuler's formula, named after Leonhard Euler, is a mathematical formula in complex analysis that establishes the fundamental relationship between the trigonometric functions and the complex exponential function. Euler's formula states that for any real number x: where e is the base of the natural logarithm, i is the imaginary unit, and cos and sin are the trigonometric functions cosine and sine respectively. This complex exponential function is sometimes denoted cis x ("cosine plus i sine").
Mortal sinA mortal sin (peccatum mortale), in Catholic theology, is a gravely sinful act which can lead to damnation if a person does not repent of the sin before death. It is alternatively called deadly, grave, and serious. A sin is considered to be "mortal" when its quality is such that it leads to a separation of that person from God's saving grace. Three conditions must together be met for a sin to be mortal: "Mortal sin is sin whose object is grave matter and which is also committed with full knowledge and deliberate consent.
Christian views on sinIn Christianity, 'sin' is an immoral act considered to be a transgression of divine law. The doctrine of sin is central to the Christian faith, since its basic message is about redemption in Christ. Hamartiology, a branch of Christian theology which is the study of sin, describes sin as an act of offence against God by despising his persons and Christian biblical law, and by injuring others. Christian hamartiology is closely related to concepts of natural law, moral theology and Christian ethics.
Trigonometric functionsIn mathematics, the trigonometric functions (also called circular functions, angle functions or goniometric functions) are real functions which relate an angle of a right-angled triangle to ratios of two side lengths. They are widely used in all sciences that are related to geometry, such as navigation, solid mechanics, celestial mechanics, geodesy, and many others. They are among the simplest periodic functions, and as such are also widely used for studying periodic phenomena through Fourier analysis.
Original sin'Original sin' is the Christian doctrine that holds that humans, through the fact of birth, inherit a tainted nature with a proclivity to sinful conduct in need of regeneration. The biblical basis for the belief is generally found in Genesis 3 (the story of the expulsion of Adam and Eve from the Garden of Eden), in a line in Psalm 51:5 ("I was brought forth in iniquity, and in sin did my mother conceive me"), and in Paul's Epistle to the Romans, 5:12-21 ("Therefore, just as sin entered the world through one man, and death through sin, and in this way death came to all people, because all sinned").
