Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

B Cell Activation: Antibody Production

In course

BIO-479: Immunology - advances and therapeutic implications

The students acquire advanced level knowledge regarding the functioning of the (vertebrate) immune system. A strong focus is placed on the molecular mechanisms underlying innate and adaptive immune responses and their implications for medicine. ...

Description

This lecture covers B cell activation and differentiation, including the initiation of humoral immune responses, antigen recognition, isotype switching, affinity maturation, and memory B cell formation. It also discusses the distinct subsets of B cells, antigen capture mechanisms, and the role of helper T cells in antibody responses.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Official source

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (32)

B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or plasma cell.

T helper cell

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils.

T cell

T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells.

Antigen presentation

Antigen presentation is a vital immune process that is essential for T cell immune response triggering. Because T cells recognize only fragmented antigens displayed on cell surfaces, antigen processing must occur before the antigen fragment, now bound to the major histocompatibility complex (MHC), is transported to the surface of the cell, a process known as presentation, where it can be recognized by a T-cell receptor. If there has been an infection with viruses or bacteria, the cell will present an endogenous or exogenous peptide fragment derived from the antigen by MHC molecules.

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision.

Related lectures (37)

Immune System Defense

Explores the immune system's defense mechanisms, including epithelial barriers, innate immunity, adaptive immunity, B and T cells, antibodies, and immunological memory.

Immunoengineering: Introduction

Covers the basics of immunoengineering, including immune cell roles, antibody production, and defense mechanisms.

Immune System: T Cells and Antigen Presentation

Explores T cells, antigen presentation, cytotoxicity, MHC proteins, apoptosis, and vaccine principles.