Lectures related to Cell Signalling: Eucaryotes

Cell Signalling: Receptors and Pathways

Explores cell signalling mechanisms, including receptors, pathways, and signal transduction for gene regulation and cellular responses.

Tyrosine Kinases & Ras Signaling

Explores tyrosine kinases, Ras activation, lipid signaling, cancer implications, and signal transduction in cells.

Altered Pathways in Cancer: Signaling Cascades and Mutations

Explores cancer pathways, major signaling cascades, and mutations in RAS and BRAF genes.

Nuclear Transport: Small GTPases and Cellular Switches

Explains nuclear transport using small GTPases as cellular switches.

Sustained Proliferation: RTK/PI3K/mTOR Pathway in Cancer

Explores the RTK/PI3K/mTOR pathway in cancer, inhibitors, completed trials, and effects of Akt/PKB on survival and proliferation.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

Cell Patterning and Signalling Pathways

Explores cell patterning, signalling pathways, and genetic mutations in biological development.

Sustained Proliferation: Signaling Pathways and Cancer Genes

Covers sustaining proliferation in cancer cells, growth factors, receptor tyrosine kinases, signal transduction, viral oncogenes, and therapeutic opportunities.

Protein Phosphorylation: Mechanisms and Regulation

Explores protein phosphorylation, its structural effects, kinase activity, and its role in signaling and disease.

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.

Proximity-specific Ribosome Profiling

Explores proximity-specific ribosome profiling and translational dynamics with high resolution, covering translation in different cells and the ER's role in protein synthesis.

Posttranslational Modifications: Phosphorylation and Protein Phosphatases

Covers posttranslational modifications, focusing on phosphorylation and protein phosphatases, and explains kinase specificity assays and the optimal phosphorylation consensus.

Cellular Communication: Signaling Pathways and Receptors

Delves into the importance of intercellular communication and the diverse signaling pathways involved in cellular responses.

Melanocytes and Hair Color Regulation

Examines paracrine communication in melanocytes, CAMP influence on hair color, Mc4R mutations, and fur phenotypes.

Fine-grained Patterning: Lateral Inhibition

Explores the development of the vulva in C. elegans and the intricate signaling pathways involved in inducing and inhibiting gene expression.

Protein Addressing at the Endoplasmic Reticulum

Explores protein addressing at the ER, including signal recognition and translocation mechanisms.

G Protein-Coupled Receptors: Signalling Diversity Log in to Mediaspace to watch this video

Explores G protein-coupled receptors' signalling diversity, covering structure, activation, bias effects, and internalisation.

Receptors and Targeting Log in to Mediaspace to watch this video

Explores receptors, ligands, and their role in signal transduction, including the activation of the immune system and the significance of multivalency in receptor-ligand interactions.

Receptor Tyrosine Kinases: Signalling and Regulation Log in to Mediaspace to watch this video

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Cell Membrane Receptors: General Principles Log in to Mediaspace to watch this video

Explains cell membrane receptors, signal transduction, and second messengers.