Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna.
CRISPR (ˈkrɪspər) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes and provide a form of acquired immunity.
Waw ( "hook") is the sixth letter of the Semitic abjads, including Phoenician wāw , Aramaic waw , Hebrew vav ו, Syriac waw ܘ and Arabic wāw و (sixth in abjadi order; 27th in modern Arabic order). It represents the consonant w in classical Hebrew, and v in modern Hebrew, as well as the vowels u and o. In text with niqqud, a dot is added to the left or on top of the letter to indicate, respectively, the two vowel pronunciations. It is the origin of Greek Ϝ (digamma) and Υ (upsilon), Cyrillic У, Latin F and V and later Y, and the derived Latin- or Roman-alphabet letters U, and W.