Alexander FlemingSir Alexander Fleming, (6 August 1881 – 11 March 1955), was a Scottish physician and microbiologist, best known for discovering the world's first broadly effective antibiotic substance, which he named penicillin. His discovery in 1928 of what was later named benzylpenicillin (or penicillin G) from the mould Penicillium rubens is described as the "single greatest victory ever achieved over disease". For this discovery, he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain.
April 171080 – Harald III of Denmark dies and is succeeded by Canute IV, who would later be the first Dane to be canonized. 1349 – The rule of the Bavand dynasty in Mazandaran is brought to an end by the murder of Hasan II. 1362 – Kaunas Castle falls to the Teutonic Order after a month-long siege. 1492 – Spain and Christopher Columbus sign the Capitulations of Santa Fe for his voyage to Asia to acquire spices. 1521 – Trial of Martin Luther over his teachings begins during the assembly of the Diet of Worms.
Act of Settlement 1701The Act of Settlement is an Act of the Parliament of England that settled the succession to the English and Irish crowns to only Protestants, which passed in 1701. More specifically, anyone who became a Roman Catholic, or who married one, became disqualified to inherit the throne. This had the effect of deposing the remaining descendants of Charles I, other than his Protestant granddaughter Anne, as the next Protestant in line to the throne was Sophia of Hanover.
