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Course

CH-448: Photomedicine

Summary

The most important clinical diagnostic and therapeutic applications of light will be described. In addition, this course will address the principles governing the interactions between light and biological tissues, their optical properties and basic concepts in photobiology and photochemistry.

Lectures

Instructor

Georges Wagnières

Georges Wagnières received his diploma degree (MSc) in physics from the University of Lausanne, Switzerland, in 1986. He obtained his doctorate in science (PhD) in physics (Biomedical optics) from the Swiss Federal Institute of Technology at Lausanne (EPFL) in 1992 and did a postdoctoral work in the Wellman Laboratories of Photomedicine (Harvard Medical School), Boston, USA, from 1993 to 1994. He also obtained a Master degree in Management of Technology delivered by the Ecole des Hautes Etudes Commerciales (HEC) of Lausanne University and the EPFL in 2001. Georges Wagnières manages a research group active in the fields of: - Detection of early superficial cancers by fluorescence imaging. - Characterization of early superficial cancers by high magnification narrow band imaging. - In vivo and in vitro measurement of the vascular and tissular oxygen concentration by time-resolved luminescence spectroscopy and imaging. - Preclinical and clinical study of new photosensitizers for photodynamic therapy (PDT). - Treatment of neurodegenerative conditions (Alzheimer, Parkinson's diseases) by photobiomodulation. - Preclinical and clinical photodynamic therapy of inflammatory bowel diseases and atheroscerotic plaque. - Improvement of the selective vascular extravasation of chemotherapeutic agents by PDT. - Monitoring the light dosimetry during PDT by fluorescence spectroscopy and imaging. - Monitoring laser treatments of the retina by reflectance imaging. - Light dosimetry and tissue optical spectroscopy. - Radiometry. - Development of light delivery systems for biomedical applications. Georges Wagnières is also co-founder and was chairman of one spin-off companies: - Medlight SA, founded in July 1997, which develops, produces and commercializes light distributors for photodynamic therapy. Georges Wagnières has currently authored more than 235 papers (more than 150 in international journals with review board) and is inventor of 18 patents. He supervised 12 PhD students up to now, and currently teaches biomedical optics and photomedicine in master programs and doctoral schools. In addition, he gives the course entitled "Physique Générale I" to biology first year students registered to the Biology School of the Lausanne's University. MAIN PUBLICATIONS Please visit: https://www.epfl.ch/labs/lifmet/wagnieres/publications/

Official source

Moodle Page

http://go.epfl.ch/CH-448

Summary

Lectures

Instructor

Georges Wagnières

Official source

Moodle Page

http://go.epfl.ch/CH-448

Lectures in this course (23)

Fluorescence Lifetime in Photomedicine

Explores fluorescence lifetime in photomedicine, covering health effects of artificial light, fluorescence guided surgery, and applications of optical spectroscopy.

Photomedicine: Introduction

Introduces the field of photomedicine, focusing on the study and treatment of diseases using light.

Radiative Transport Equation

Explores the Radiative Transport Equation in tissue optics, covering radiance, photon distribution, and numerical solutions like Monte Carlo simulations.

Radiative Transport Equation

Explores the Radiative Transport Equation in tissue optics, covering radiance, photon distribution, fluence rate, and solution methods.

Approximations of the RTE

Explores the Kubelka-Munk theory and diffusion approximation in tissue optics.

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