Angioedema

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

Christian Heinis, Alessandro Zorzi, Jonas Alfred Karl Wilbs, Kaycie Marie Butler, Simon Jan Middendorp

The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' ...

Nature Research2017

Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity

Christian Heinis, Jonas Alfred Karl Wilbs, Simon Jan Middendorp

Factor XII (FXII) is a plasma protease that has emerged in recent years as a potential target to treat or prevent pathological thrombosis, to inhibit contact activation in extracorporeal circulation, and to treat the swelling disorder hereditary angioedema ...

2017

Fabric evolution and the related swelling behaviour of a sand/bentonite mixture upon hydro-chemo-mechanical loadings

Lyesse Laloui, Alessio Ferrari, Donatella Manca

This experimental study investigates the swelling behaviour of an 80/20 sand/bentonite mixture and the associated fabric evolution under different hydro-chemo-mechanical loadings. Free and confined swelling tests are performed on specimens compacted to dif ...

Ice Publishing2016

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

John McKinney, Neeraj Dhar, François Signorino-Gelo, Katrin Esther Schneider

Exposure of an isogenic bacterial population to a cidal antibiotic typically fails to eliminate a small fraction of refractory cells. Historically, fractional killing has been attributed to infrequently dividing or nondividing "persisters." Using microflui ...

American Association for the Advancement of Science2013