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Concept

Cortical column

Related publications (32)

Cortical sensory processing across motivational states during goal-directed behavior

Carl Petersen, Georgios Foustoukos, Matthieu Pierre Auffret, Sami El-Boustani, Johannes Maria Mayrhofer

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker disc ...

2022

Neuromodulation of neocortical microcircuitry: a multi-scale framework to model the effects of cholinergic release

Cristina Colangelo

Neuromodulation of neocortical microcircuits is one of the most fascinating and mysterious aspects of brain physiology. Despite over a century of research, the neuroscientific community has yet to uncover the fundamental biological organizing principles un ...

EPFL2022

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Traian Popa

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...

ELSEVIER IRELAND LTD2022

Spike frequency adaptation supports network computations on temporally dispersed information

Guillaume Emmanuel Fernand Bellec

For solving tasks such as recognizing a song, answering a question, or inverting a sequence of symbols, cortical microcircuits need to integrate and manipulate information that was dispersed over time during the preceding seconds. Creating biologically rea ...

2021

In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations

Henry Markram, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Grigori Chevtchenko, Taylor Howard Newton

Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cortical neurons, but with effective resolution limits that confound interpretation. To address this limitation, we developed an in ...

Nature Research2021

The Role of Hub Neurons in Modulating Cortical Dynamics

Henry Markram, Felix Schürmann, Idan Segev

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

2021

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice

Maria del Carmen Sandi Perez

The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...

2021

Cortical Surfaces Integration with Tractography for Structural Connectivity Analysis

Gabriel Girard, Maxime Descoteaux

Background: Mapping diffusion MRI tractography streamlines to the cortical surface facilitates the integration of white matter features onto gray matter, especially for connectivity analysis. ...

MARY ANN LIEBERT, INC2021

Anatomical and functional characterization of neocortical circuits involved in transforming whisker sensory processing into goal-directed licking

Georgios Foustoukos

The choice of an action upon perception of an external stimulus, arriving at a sensory organ of an animal, depends on previous experiences and outcomes throughout its life. In the rodent brain, the underlying mechanisms involved in simple sensorimotor tran ...

EPFL2022

Target cell-type specificity of a cortico-amygdala long range synaptic connection

Ayah Khubieh

An important function of the brain is to analyze sensory information, and to modulate animal behaviour according to previous experience. During processes of emotional learning, sensory percepts with a reinforcing quality, also called unconditioned stimuli ...

EPFL2021

A community-based transcriptomics classification and nomenclature of neocortical cell types

Parviz Ghaderi

To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal or glia ...

NATURE PUBLISHING GROUP2020

Pansynaptic Enlargement at Adult Cortical Connections Strengthened by Experience

Graham Knott

Behavioral experience alters the strength of neuronal connections in adult neocortex. These changes in synaptic strength are thought to be central to experience-dependent plasticity, learning, and memory. However, it is not known how changes in synaptic tr ...

Oxford University Press2014