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Concept

Triune brain

Related publications (29)

Motion-Correction Enabled Ultra-High Resolution In-Vivo 7T-MRI of the Brain

Daniel Gallichan

OBJECTIVES: To demonstrate the image quality that can be obtained for multiple contrasts using ultra-high resolution MRI (highest nominal resolution: 350 mum isotropic) at 7T using appropriate motion-correction. MATERIALS AND METHODS: An MRI-based fat-exci ...

Public Library of Science2016

Motor and cognitive brain circuits of brain-machine interactions

Silvia Marchesotti

Brain-machine interfaces (BMIs) allow the user to control an external device such as a robotic arm, a cursor, or an avatar in a virtual world through the real-time decoding of brain signals and without the involvement of the musculoskeletal system. Althoug ...

EPFL2016

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

Henry Markram, Srikanth Ramaswamy

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition

Carl Petersen

The basal forebrain (BF) houses major ascending projections to the entire neocortex that have long been implicated in arousal, learning, and attention. The disruption of the BF has been linked with major neurological disorders, such as coma and Alzheimer's ...

Soc Neuroscience2015

Motor Control in the Mouse Whisker System

Varun Sreenivasan

The motor systems of the mammalian brain are a remarkable product of many millions of years of evolution. It is the motor systems that make us and other mammals mobile, that guide our actions in response to sensory information and conversely modulate the v ...

EPFL2015

In vivo measurement of excitatory synaptic transmission between identified neurons in layer 2/3 mouse barrel cortex

Aurélie Pala

The neocortex is the most distinctive feature of the mammalian brain and it is considered to be the substrate of high-order cognitive functions. The nature and the arrangement of the diverse neuronal elements constituting its multiple areas have received l ...

EPFL2014

Computational Neuroscience Breakthroughs Through Innovative Data Management

Anastasia Ailamaki, Thomas Heinis, Farhan Tauheed

Simulations have become key in many scientific disciplines to better understand natural phenomena. Neuroscientists, for example, build and simulate increasingly fine grained models (including subcellular details, e.g., neurotransmitter) of the neocortex to ...

2013

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Liliane Glauser, Sarah Catherine Sonnay, Elpida Tsika, Klodjan Stafa, Alzbeta Trancikova, Agata Podhajska

Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P-5-type ATPase subfamily that is predicted to regulate t ...

Oxford University Press2012

GABA Signaling Promotes Synapse Elimination and Axon Pruning in Developing Cortical Inhibitory Interneurons

Graham Knott

Accumulating evidence indicates that GABA acts beyond inhibitory synaptic transmission and regulates the development of inhibitory synapses in the vertebrate brain, but the underlying cellular mechanism is not well understood. We have combined live imaging ...

2012