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Concept

Calcium sparks

Related publications (11)

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Johan Auwerx, Tanes Imamura de Lima

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

Nature Portfolio2021

Could Macroscopic Dark Matter (Macros) Give Rise to Mini-Lightning Flashes out of a Blue Sky without Clouds?

Farhad Rachidi-Haeri, Marcos Rubinstein

A recent study pointed out that macroscopic dark matter (macros) traversing through the Earth’s atmosphere can give rise to hot and ionized channels similar to those associated with lightning leaders. The authors of the study investigated the possibility t ...

2021

Fully Eulerian finite element approximation of a fluid-structure interaction problem in cardiac cells

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Aymen Laadhari

We propose in this paper an Eulerian finite element approximation of a coupled chemical fluid-structure interaction problem arising in the study of mesoscopic cardiac biomechanics. We simulate the active response of a myocardial cell (here considered as an ...

Wiley-Blackwell2013

A silicon model of the inner hair cell

Yusuf Leblebici

In this paper we present an electrical model of the inner hair cell based on an improved mathematical model. The model is implemented in silicon in the current domain using translinear circuits. It improves on previous models by taking into consideration t ...

2011

Synaptotagmin increases the dynamic range of synapses by driving Ca2+ - evoked release and by clamping a near-linear remaining Ca2+ sensor

Ralf Schneggenburger, Olexiy Kochubey

Ca2+-evoked transmitter release shows a high dynamic range over spontaneous release. We investigated the role of the Ca2+ sensor protein, Synaptotagmin2 (Syt2), in both spontaneous and Ca2+-evoked release under direct control of presynaptic Ca2+, usin ...

2011

Propagation of fast and slow intercellular Ca2+ waves in primary cultured arterial smooth muscle cells

Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi

Smooth muscle contraction is regulated by changes in cytosolic Ca2+ concentration (Ca2+). In response to stimulation, Ca2+ increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca2+ waves. To investigate ...

2011

Mechanisms of Propagation of Intercellular Calcium Waves in Arterial Smooth Muscle Cells

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Dominique Seppey

In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...

Elsevier2010

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Dominique Seppey

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

"Chemosensory perception", the perception of food chemicals, relies on the complex cooperation of gustatory, olfactory and somatosensory detection systems. In the oral cavity, the taste buds and the lingual branch of the trigeminal nerve are the organs tha ...

EPFL2008

A theoretical model of the cellular calcium dynamics and vasomotion in muscular arteries

Michèle Koenigsberger

Muscular arteries possess the ability to control actively their lumen by altering the tone of the smooth muscle cells of the arterial wall, a property which is vital for a large number of the hemodynamical functions of the body. Arterial contraction is due ...

EPFL2006

Calcium dynamics and intercellular communication in arterial smooth muscle cells

Mathieu Lamboley

This thesis is a contribution to the field of cellular communication in arteries during vasomotion, i.e. rhythmic and spontaneous diameter oscillations of arteries. Investigating how individual smooth muscle cells (SMCs) and endothelial cells (ECs) calcium ...

EPFL2005