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Concept

Morris water navigation task

Related publications (28)

Neuron-glia metabolic coupling and plasticity

Pierre Magistretti

The focus of the current research projects in my laboratory revolves around the question of metabolic plasticity of neuron-glia coupling. Our hypothesis is that behavioural conditions, such as for example learning or the sleep-wake cycle, in which synaptic ...

Wiley-Blackwell2011

Path planning versus cue responding: a bioinspired model of switching between navigation strategies

Ricardo Andres Chavarriaga Lozano

In this paper we describe a new computational model of switching between path-planning and cue-guided navigation strategies. It is based on three main assumptions: (i) the strategies are mediated by separate memory systems that learn independently and in p ...

Springer Verlag2010

Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

Maria del Carmen Sandi Perez

Neural cell adhesion molecule (NCAM)-mediated cell adhesion results in activation of intracellular signaling cascades that lead to cellular responses such as neurite outgrowth, neuronal survival, and modulation of synaptic activity associated with cognitiv ...

2010

Learning under stress: the inverted-U-shape function revisited

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Basira Salehi

Although the relationship between stress intensity and memory function is generally believed to follow an inverted-U-shaped curve, strikingly this phenomenon has not been demonstrated under the same experimental conditions. We investigated this phenomenon ...

Cold Spring Harbor Laboratory Press2010

User interaction with online geospatial systems

Jens Ingensand

User interaction with online geospatial systems is an inter-disciplinary research field that combines the two disciplines Human Computer Interaction (HCI) and geographic information sciences. In recent years online geospatial systems have been created for ...

EPFL2010

Is there a geometric module for spatial orientation? Insights from a rodent navigation model

Wulfram Gerstner, Ricardo Andres Chavarriaga Lozano, Thomas Strösslin

Modern psychological theories of spatial cognition postulate the existence of a geometric module for reorientation. This concept is derived from experimental data showing that in rectangular arenas with distinct landmarks in the corners, disoriented rats o ...

American Psychological Association2009

The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

Maria del Carmen Sandi Perez

Agomelatine, a novel antidepressant with established clinical efficacy, acts as a melatonin receptor agonist and 5-HT(2C) receptor antagonist. As stress is a significant risk factor in the development of depression, we sought to determine if chronic agomel ...

Cambridge University Press2009

Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule

Maria del Carmen Sandi Perez, Thomas Brionne

In this study, we examined whether chronic stress in adulthood can exert long-term effects on spatial-cognitive abilities and on the survival of newborn hippocampal cells in aging animals. Male Wistar rats were subjected to chronic unpredictable stress at ...

Lippincott, Williams & Wilkins2008