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Concept

Dendrite

Related publications (30)

Principles of Network Plasticity in Neocortical Microcircuits

András Ecker

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

EPFL2023

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, András Ecker, Pramod Shivaji Kumbhar, Giuseppe Chindemi, Daniela Egas Santander, James Bryden Isbister, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

Cortical cell assemblies and their underlying connectivity: an in silico study

Michael Reimann, András Ecker, Daniela Egas Santander, James Bryden Isbister, Sirio Bolaños Puchet

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

2024

NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways

Willem Anna Mark Wybo, Bernd Albert Illing

While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contex-tual sta ...

National Academy of Sciences2023

Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas

Carl Petersen, Sylvain Crochet, Georgios Foustoukos, Yanqi Liu

Communication between cortical areas contributes importantly to sensory perception and cognition. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. ...

FRONTIERS MEDIA SA2022

A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines

Graham Knott, Jérôme Blanc

Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided ...

NATURE PORTFOLIO2022

Revealing Morphology Evolution of Lithium Dendrites by Large-Scale Simulation Based on Machine Learning Force Field

Mouyi Weng

Solving the dendrite growth problem is critical for the development of lithium metal anode for high-capacity batteries. In this work, a machine learning force field model in combination with a self-consistent continuum solvation model is used to simulate t ...

WILEY-V C H VERLAG GMBH2022

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

James Gonzalo King, Suraj Honnuraiah

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...

2022

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Traian Popa

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...

ELSEVIER IRELAND LTD2022

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner

Michele De Palma

Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the ...

CELL PRESS2021

In situ visualizing the interplay between the separator and potassium dendrite growth by synchrotron X-ray tomography

Kangning Zhao, Yutao Li, Yanan Chen

Rechargeable potassium (K) batteries are a promising next-generation technology for low-cost grid scale energy storage applications. Nevertheless, the undesirable interfacial instabilities originating from the interplay between the employed separators and ...

Elsevier2021

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Olivier Burri, Evelyne Ruchti, Brian Donal McCabe, Wei Jiao, Soumya Banerjee, Samuel William Vernon

The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...

Nature Research2021

Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins

Greta Limoni

The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic co ...

MDPI2021

Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice

Maria del Carmen Sandi Perez

The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...

2021

The Target of Exuberant Projections in Development

Giorgio Innocenti

In addition to neuronal death and elimination of synapses, the production of transient, exuberant axons, and axonal branches is a general phenomenon in development across species and systems. To understand what drives the decision of which axons are mainta ...

2020

Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose

Rolf Gruetter, Hongxia Lei, Bernard Lanz, Carole Poitry-Yamate, Antoine Timothée Cherix, Guillaume Donati, Blanca Lizarbe Serra

Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...

2021

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq

The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...

2020

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Dendritic Voltage Recordings Explain Paradoxical Synaptic Plasticity: A Modeling Study

Wulfram Gerstner, Laureline Logiaco

Experiments have shown that the same stimulation pattern that causes Long-Term Potentiation in proximal synapses, will induce Long-Term Depression in distal ones. In order to understand these, and other, surprising observations we use a phenomenological mo ...

FRONTIERS RESEARCH FOUNDATION2020

Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship

Jean-Philippe Thiran, Jonathan Rafael Patino Lopez

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional ...

National Academy of Sciences2020