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The Indiana University School of Medicine (IUSM) is a major, multi-campus medical school located throughout the U.S. state of Indiana and is the graduate medical school of Indiana University. There are nine campuses throughout the state; the principal research, educational, and medical center is located on the Indiana University–Purdue University Indianapolis (IUPUI) campus in Indianapolis. With 1,452 MD students, 203 PhD students, and 1,356 residents and fellows in the 2022–23 academic year, IUSM is the largest medical school in the United States. The school offers many joint degree programs including an MD/PhD Medical Scientist Training Program. It has partnerships with Purdue University's Weldon School of Biomedical Engineering, other Indiana University system schools, and various in-state external institutions. It is the medical school with the largest number of graduates licensed in the United States per a 2018 Federation of State Medical Boards survey with 11,828 licensed physicians. The school has pioneered research in multiple specialties, including oncology, immunology, substance use, neuroscience, and endocrinology. Research discoveries include a curative therapy for testicular cancer, the development of echocardiography, the identification of several genes linked to Alzheimer's disease, and the creation of inner ear sensory cells from pluripotent stem cells. In the 2023 U.S. News & World Report rankings of the best graduate schools for medicine, the school ranked 23rd in the nation for primary care and 41st for research out of 192 medical schools. In the U.S. News & World Report rankings of the best hospitals, the Indiana University Health Medical Center had seventeen nationally ranked clinical programs. The Riley Hospital for Children at Indiana University Health is nationally ranked in 9 of 10 designated specialties for children in the U.S. News & World Report. The IU School of Medicine is also home to the Melvin and Bren Simon Comprehensive Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center.