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Concept

Experimental evolution

Related publications (28)

Experimental adaptation of human echovirus 11 to ultraviolet radiation leads to tolerance to disinfection and resistance to ribavirin

Tamar Kohn, Jeffrey David Jensen, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong, Hyunjin Shim

Ultraviolet light in the UVC range is a commonly used disinfectant to control viruses in clinical settings and water treatment. Here, we employed an experimental evolution approach to investigate the adaptation of human echovirus 11 to disinfection by UVC, ...

2017

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness

Tamar Kohn, Jeffrey David Jensen, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong, Hyunjin Shim

Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evo ...

Amer Chemical Soc2017

Inferring the age and strength of mutations evolving under positive selection

Nicky Louise Ormond

A fundamental goal of population genetics is to determine and quantify the interplay of mutation, natural selection, genetic drift and migration in shaping allelic frequency changes that underpin evolution-ary change. In this dissertation, I present comput ...

EPFL2017

NEMo: An Evolutionary Model With Modularity for PPI Networks

Bernard Moret, Xiuwei Zhang, Min Ye

Modeling the evolution of biological networks is a major challenge. Biological networks are usually represented as graphs; evolutionary events not only include addition and removal of vertices and edges but also duplication of vertices and their associated ...

IEEE Press2017

A unified measure of linear and nonlinear selection on quantitative traits

Yoav Zemel

Lande and Arnold's approach to quantifying natural selection has become a standard tool in evolutionary biology due to its simplicity and generality. It treats linear and nonlinear selection in two separate frameworks, generating coefficients of selection ...

Wiley2017

Atomistic Simulations of the Crystallization and Aging of GeTe Nanowires

Davide Campi, Edoardo Baldi

Nanowires made of chalcogenide alloys are of interest for use in phase-change nonvolatile memories. For this application, insights into the thermal properties of such nanowires and, in particular, into the crystallization kinetics at the atomic level are c ...

American Chemical Society2017

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

Melanie Blokesch

Natural competence enables bacteria to take up exogenous DNA. The evolutionary function of natural competence remains controversial, as imported DNA can act as a source of substrates or can be integrated into the genome. Exogenous homologous DNA can also b ...

Nature Publishing Group2017

An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data

Jeffrey David Jensen

The joint and accurate inference of selection and demography from genetic data is considered a particularly challenging question in population genetics, since both process may lead to very similar patterns of genetic diversity. However, additional informat ...

Genetics Society America2016