Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Concept

Scar

Related publications (22)

First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting

Biranche Tandon

In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...

Wiley-V C H Verlag Gmbh2024

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

Boris Hinz, Jean-Jacques Meister, Josiane Angèle Charlotte Smith-Clerc, Lara Buscemi Estefanell

Changes in the mechanical properties of dermis occur during skin aging or tissue remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic culture substrates that reproduce the variable softness of dermis, we determined ...

Nature Publishing Group2014

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Stéphanie Lacour

Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative ...

Shenyang Editorial Dept Neural Regeneration Res2014

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Jeffrey Alan Hubbell

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez, Marco Pisano

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Marcin Stefan Zielinski

Therapeutic regulation of tissue vascularization has appeared as an attractive approach to treat a number of human diseases. In vivo neovascularization assays that reflect physiological and pathological formation of neovessels are important in this effort. ...

Springer Netherlands2012

Biologicals and fetal cell therapy for wound healing and scar management

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

Few biopharmaceutical preparations developed from biologicals are available for tissue regeneration and scar management. When developing biological treatments with cellular therapy, selection of cell types and establishment of consistent cell banks are cru ...

2011

Coordination of Myofibroblast Contraction in Vitro

Lysianne Follonier Castella

The aim of this thesis is to elucidate the common mechanisms that regulate myofibroblast contraction and intercellular communication, with a particular focus on the role of Ca2+ signalling. Synthesis and remodelling of collagenous matrix by myofibroblasts ...

EPFL2010

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Boris Hinz

Ischemic wounds are characterized by oxygen levels lower than that of healthy skin ( hypoxia) and poor healing. To better understand the pathophysiology of impaired wound healing, we investigated how switching from high ( 21%) to low ( 2%) oxygen levels di ...

Nature Publishing Group2010

Design and Psychophysical Evaluation of a Tactile Pulse Display for Teleoperated Artery Palpation

Hannes Bleuler, Philippe Rétornaz, Roger Gassert, Laura Santos Carreras

During traditional open procedures, surgeons directly palpate tissues before dissecting them. In this way, they can avoid the accidental damage of hidden arteries that can lead to fatal hemorrhage. New Minimally Invasive Surgical (MIS) techniques progressi ...

IEEE2010

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell, Lysianne Follonier Castella

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

Myofibroblasts work best under stress

Boris Hinz

Myofibroblasts are reparative connective tissue cells that contribute to the reconstruction of injured tissue by secreting new extracellular matrix and by exerting high contractile force. Deregulation of these activities results in tissue contracture and d ...

Elsevier2009

Myofibroblast communication is controlled by intercellular mechanical coupling

Boris Hinz, Jean-Jacques Meister, Sébastien Schaub, Lysianne Follonier Castella

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical couplin ...

Company of Biologists2008

Mechanical orchestration of tissue remodeling

After organ injury, a complex sequence of events is triggered to heal the tissue and to form a scar. Myofibroblasts, specialized contractile and secretory fibroblasts, are one of the many cell types that participate in the remodeling process. Myofibroblast ...

EPFL2008

The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts

Boris Hinz

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, i ...

Elsevier2008

Wound repair and regeneration

Yann Barrandon

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonl ...

2008

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures

Melody Swartz

Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and ...

Springer US2006

Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity

Boris Hinz

During wound healing and fibrocontractive diseases fibroblasts acquire a smooth muscle cell-like phenotype by differentiating into contractile force generating myofibroblasts. We examined whether regulation of myofibroblast contraction in granulation tissu ...

Wiley-Blackwell2006