Concept

Sodium-calcium exchanger

Related publications (28)

Ricca's factors as mobile proteinaceous effectors of electrical signaling

Leaf-feeding insects trigger high-amplitude, defense-inducing electrical signals called slow wave potentials (SWPs). These signals are thought to be triggered by the long-distance transport of low molecular mass elicitors termed Ricca's factors. We sought ...

CELL PRESS2023

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses

Maria Reva

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synap-tic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger rel ...

CELL PRESS2022

Al uptake in calcium silicate hydrate and the effect of alkali hydroxide

Karen Scrivener, Yan Yan

The effect of Al and of pH on the structure of calcium silicate hydrate (C-S-H), the most important hydration product in Portland and blended cement, was studied at Ca/Si similar to 1.0. The presence of Al led to higher amounts of secondary phases, larger ...

Pergamon-Elsevier Science Ltd2022

A modeling framework to understand and optimize ultrasound neuromodulation

Théo Lemaire

Over the last decade, Low Intensity Focused Ultrasound Stimulation (LIFUS) has emerged as an attractive technology to modulate the activity of deep neural targets without invasive procedures. However, the underlying mechanisms by which ultrasonic waves can ...

EPFL2021

Passive and active ion permeation through lipid bilayers investigated by second harmonic water imaging

Maksim Eremchev

Lipid membranes are complex and dynamic systems which are known to mediate signaling processes between cells and their environment. To do this multiple ion channels and pumps are involved in controlling the in- and out-flux of various ions (K+, Na+, Mg2+, ...

EPFL2021

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Alfio Quarteroni, Francesco Regazzoni

Author summary Computer-based numerical simulations of the heart are increasingly assuming a recognized role in the context of computational medicine and cardiology. They are based on mathematical models describing the different physical phenomena occurrin ...

2020

Enhancing the Signaling of GPCRs via Orthosteric Ions

Horst Arthur Vogel, Shuguang Yuan

G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

AMER CHEMICAL SOC2020

Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

Françoise Gisou van der Goot Grunberg, Sylvia Ho

Pore-forming toxins (PFTs) form holes in membranes causing one of the most catastrophic damages to a target cell. Target organisms have evolved a regulated response against PFTs damage including cell membrane repair. This ability of cells strongly depends ...

Elsevier Science Bv2017

Sodium Signaling and Astrocyte Energy Metabolism

Pierre Magistretti

The Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is ...

Wiley-Blackwell2016

Cortical neurons gradually attain a post-mitotic state

Johannes Gräff

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Matteo Dal Peraro, Thomas Lemmin

P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has re ...

National Academy of Sciences2014

Kinetics of xylem loading, membrane potential maintenance, and sensitivity of K+-permeable channels to reactive oxygen species: physiological traits that differentiate salinity tolerance between pea and barley

Amandine Massart

Salt sensitive (pea) and salt tolerant (barley) species were used to understand the physiological basis of differential salinity tolerance in crops. Pea plants were much more efficient in restoring otherwise depolarized membrane potential thereby effective ...

Wiley-Blackwell2014

Mathematical modelling of active contraction in isolated cardiomyocytes

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi, Aymen Laadhari

We investigate the interaction of intracellular calcium spatio-temporal variations with the self-sustained contractions in cardiac myocytes. A consistent mathematical model is presented considering a hyperelastic description of the passive mechanical prope ...

Oxford University Press2014

Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells

Martinus Adela Maria Gijs, Paolo Silacci, Hüseyin Cumhur Tekin, Josias Basil Wacker

The absorption of dietary calcium through the intestinal barrier is essential for maintaining health in general and especially of the bone system. We propose a microfluidic model that studies free calcium (Ca2+) transport through a confluent monolayer of C ...

Royal Soc Chemistry2014

On chip cellular dielectric spectroscopy : monitoring of glucose effect on erythrocytes membrane and analysis of the physiological role of anthrax toxin receptor in endothelial cells

Ludovica Colella

In the recent years, the development of automated systems for cellular monitoring has been highly promoted in basic biological research as well as in industries and medical diagnostic. Several methods for transduction of cellular signals have been investig ...

EPFL2012

A silicon model of the inner hair cell

Yusuf Leblebici

In this paper we present an electrical model of the inner hair cell based on an improved mathematical model. The model is implemented in silicon in the current domain using translinear circuits. It improves on previous models by taking into consideration t ...

2011

Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large CNS synapse

Ralf Schneggenburger, Olexiy Kochubey

Transmitter release at synapses is driven by elevated intracellular Ca2+ concentration (Ca2+) near the sites of vesicle fusion. Ca2+ signals of profoundly different amplitude and kinetics drive the phasic release component during a presynaptic ac ...

2011

Propagation of fast and slow intercellular Ca2+ waves in primary cultured arterial smooth muscle cells

Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi

Smooth muscle contraction is regulated by changes in cytosolic Ca2+ concentration (Ca2+). In response to stimulation, Ca2+ increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca2+ waves. To investigate ...

2011

Calcium Dynamics and Intercellular Communication in Arterial Smooth Muscle Cells in Vitro

Nadia Halidi

Tissue blood flow is controlled by changes in the diameter of the arteries and arterioles through coordinated contraction and relaxation of smooth muscle cells (SMCs) within the vascular wall. The contraction of SMCs is primarily regulated by the intracell ...

EPFL2011

Cellular Dynamics and Three-Dimensional Refractive Index Distribution Studied with Quantitative Phase Imaging

Nicolas Pavillon

We present in this PhD thesis work various applications of digital holographic microscopy (DHM), an imaging technique based on coherent illumination which enables the recovery of the full complex wavefront, i.e. the amplitude and phase of a wave field whic ...

EPFL2011