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Concept

Adaptive design (medicine)

Related publications (16)

Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial

Sebastian Martin Waszak

PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...

2023

Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Sebastian Martin Waszak

Diffuse midline glioma (DMG) is a devastating pediatric brain tumor unresponsive to hundreds of clinical trials. Approximately 80% of DMGs harbor H3K27M oncohistones, which reprogram the epigenome to increase the metabolic profile of the tumor cells. We ha ...

2023

Surgical management of anterior clinoidal meningiomas: consensus statement on behalf of the EANS skull base section

Constantin Tuleasca

Background The optimal management of clinoidal meningiomas (CMs) continues to be debated. Methods We constituted a task force comprising the members of the EANS skull base committee along with international experts to derive recommendations for the managem ...

2021

Peptides stimulating synthesis of extracellular matrix used in anti-ageing cosmetics: Are they clinically tested? A systematic review of the literature

Florentino Luciano Caetano Dos Santos

Peptides stimulating synthesis of extracellular matrix are now commonly used in the production of anti-ageing cosmetics. However, much uncertainty still exists about the methodology of their clinical assessment. The aim of the study was to review the liter ...

WILEY2019

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Pierre Magistretti

Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...

FRONTIERS MEDIA SA2019

Measuring transient phase-amplitude coupling using local mutual information

Here we demonstrate the suitability of a local mutual information measure for estimating the temporal dynamics of cross-frequency coupling (CFC) in brain electrophysiological signals. In CFC, concurrent activity streams in different frequency ranges intera ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

The detection of two-component mixture alternatives : Theory and methods

Daria Rukina

In this thesis, we deal with one of the facets of the statistical detection problem. We study a particular type of alternative, the mixture model. We consider testing where the null hypothesis corresponds to the absence of a signal, represented by some kno ...

EPFL2018

A methodology for designing flexible multi-generation systems

Adriano Viana Ensinas

An FMG (flexible multi-generation system) consists of integrated and flexibly operated facilities that provide multiple links between the various layers of the energy system. FMGs may facilitate integration and balancing of fluctuating renewable energy sou ...

Pergamon-Elsevier Science Ltd2016

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

Stewart Cole

About 1.3 million people died of tuberculosis in 2012, despite availability of effective drug treatment. Barriers to improvements in outcomes include long treatment duration (resulting in poor patient adherence and loss of patients to follow-up), complex r ...

Elsevier Science Inc2014

Development of a Database for Translational Spinal Cord Injury Research

Grégoire Courtine

Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of ...

Mary Ann Liebert2014

Advances in the development of new tuberculosis drugs and treatment regimens

Stewart Cole

Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide. For the first time ...

Nature Publishing Group2013

Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis

Douglas Hanahan, Ksenya Shchors

Despite their apparent success in pre-clinical trials, metalloproteinase (MMP) inhibitors proved to be inefficacious in clinical settings. In an effort to understand the underlying causes of this unanticipated outcome, we modeled the consequences of long-t ...

2013

Single trial analysis of slow cortical potentials: A study on anticipation related potentials

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Gangadhar Garipelli

Objective. Abundant literature suggests the use of Slow Cortical Potentials (SCPs) in a wide spectrum of basic and applied neuroscience areas. Due to low signal to noise ratio, often these potentials are studied using grand-average analysis, which conceal ...

Institute of Physics2013

Real-time Prediction of Fast and Slow Delivery of Mental Commands in a Motor Imagery BCI: An Entropy-based Approach

José del Rocio Millán Ruiz, Michael Christoph Gastpar, Ricardo Andres Chavarriaga Lozano, Sareh Saeedi

Providing adaptive shared control for Brain- Computer Interfaces (BCIs) can result in better performance while reducing the user’s mental workload. In this respect, online estimation of accuracy and speed of command delivery are important factors. This stu ...

2012

Single Trial Recognition of Anticipatory Slow Cortical Potentials: The Role of Spatio-Spectral Filtering

José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Gangadhar Garipelli

Single trial recognition of slow cortical potentials (SCPs) from full-band EEG (FbEEG) faces different challenges to classical EEG such as noisy, high magnitude (~±100µV) infra slow oscillations (ISO) with f

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells

Florian Maria Wurm, Lucia Baldi Unser, Mathieu Benjamin Stettler

Adeno-associated virus (AAV)-based vectors belong to the most promising gene transfer vectors in clinical studies. To provide vector for late-stage clinical trials as well as for a potential commercial phase, a scalable, cGMP-compliant process is required. ...

Springer, Springer Netherlands2007