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Concept

Antiarrhythmic agent

Related publications (17)

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Alfio Quarteroni, Luca Dede'

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Computational methods for live heart imaging with speed-constrained microscopes

Olivia Mariani

Imaging methods to capture the beating and developing heart inside embryonic animal models such as the zebrafish are a key component for the study of fundamental biological processes such as cardiac birth defects or tissue regeneration. However, live heart ...

EPFL2021

Heart Rate Variability Triangular Index as a Predictor of Cardiovascular Mortality in Patients With Atrial Fibrillation

Jean-Marc Vesin, Vincent Schlageter

Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive o ...

2020

Ultrasound Stimulations Induce Prolonged Depolarization and Fast Action Potentials in Leech Neurons

Silvestro Micera, Théo Lemaire

Objective: Ultrasound (US) stimulation carries the promise of a selective, reversible, and non-invasive modulation of neural activity without the need for genetic manipulation of neural structures. However, the mechanisms of US-induced generation of action ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging

Pierre Marquet, Gerardo Turcatti, Benjamin Rappaz, Fabien Kuttler, Bokyoung Kim

We use quantitative phase digital holographic microscopy (QP-DHM) to image and quantify the beating movement of cardiomyocytes, derived from induced pluripotent stem cells (iPSCs), in control and drug-treated conditions. The development of an analysis algo ...

AMER CHEMICAL SOC2020

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

Stamatia Zoi Pagoulatou

Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...

EPFL2020

Cortical reactive balance responses to unexpected slippages while walking: a pilot study

Silvestro Micera

Understanding how the human brain cortex behaves when the dynamical balance is unexpectedly challenged can be useful to enable fall prevention strategies during daily activities. In this respect, we designed and tested a novel methodological approach to ea ...

IEEE2019

Severe and uniform bi-atrial remodeling measured by dominant frequency analysis in persistent atrial fibrillation unresponsive to ablation

Jean-Marc Vesin, Etienne Pruvot, Andréa Buttu, Adrian Luca

Background High values of ECG and intracardiac dominant frequency (DF) are indicative of significant atrial remodeling in persistent atrial fibrillation (peAF). We hypothesized that patients with peAF unresponsive to ablation display higher ECG and intraca ...

2020

Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free-Behaving Sheep Model

Jean-Marc Vesin, Etienne Pruvot, Florian Jousset

Repolarization Alternans and Atrial Remodeling Introduction Paroxysmal atrial fibrillation (AF) may be triggered by intermittent atrial tachycardia, and ultimately lead to persistent AF. However, the mechanisms by which intermittent atrial tachycardia prom ...

Wiley-Blackwell2014

Correlation Dimension as a Measure of the Atrial Fibrillation Capture during Atrial Septal Pacing

Jean-Marc Vesin, Adrian Luca

In the present model-based study, the correlation dimension (D2) was used as a measure of the effectiveness of atrial septal pacing during atrial fibrillation (AF). From ongoing simulated atrial fibrillation, instantaneous transmembrane potential maps were ...

2014

Kinetics of Atrial Repolarization Alternans in a Free-Behaving Ovine Model

Jean-Marc Vesin, Etienne Pruvot, Florian Jousset

Kinetics of Atrial Repolarization Alternans. Introduction: Repolarization alternans (Re-ALT), a beat-to-beat alternation in action potential repolarization, promotes dispersion of repolarization, wavebreaks, and reentry. Recently, Re-ALT has been shown to ...

Wiley-Blackwell2012

Characterization of Atrial Repolarization Alternans and Activation Time Kinetics based on Intracardiac Electrograms

Florian Jousset

Interdisciplinary collaboration between physicians and engineers is now widespread in fundamental and clinical studies, due to the increasing complexity of the physiological problems tackled, and the development of novel measurement devices and data analys ...

EPFL2011

Harmonic frequency tracking algorithm for predicting the success of pharmacological cardioversion of atrial fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry, Andréa Buttu, Jérôme Sébastien Van Zaen

Purpose: Non-invasively predicting the success of pharmacological cardioversion for patients with atrial fibrillation (AF) would be of great interest in clinical settings. In this study, an adaptive algorithm for tracking fundamental and harmonic component ...

2011

Nanostructured titania coatings for drug-eluting medical implants

Medical implants delivering drugs are used to ensure efficient medication at body sites, at which the conventional administration of drugs is insufficient. The application of drug-delivery coatings is a beneficial concept for implants exposed to mechanical ...

EPFL2009

Data processing techniques for the characterization of atrial fibrillation

Mathieu Lemay

Atrial fibrillation is the most common sustained cardiac rhythm disturbance, increasing in prevalence with age. During the past 20 years, there has been a 66% increase in hospital admissions related to atrial fibrillation. Neither the natural history of at ...

EPFL2008

Design and performance of lead systems for the analysis of atrial signal components in the ECG

Zenichi Ihara

For over a century, electrocardiology has been observing human cardiac activity through recordings of electrocardiograms (ECG). The potential differences derived from the nine electrodes of the standard 12-lead ECG, placed at their designated positions, ar ...

EPFL2006

Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity

Wulfram Gerstner

We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiologi ...

American Physiological Society2005