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Concept

Aminoglycoside

Related publications (23)

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

Meltem Elitas

Bacterial cells behave as individuals despite being genetically identical and subject to the same environment. Although the underlying mechanisms of cellular individuality are not well understood, temporal variation of gene expression and protein levels in ...

EPFL2012

Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Sandrine Gerber, Gérald Coste

Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues bas ...

2011

New efficient synthetic routes toward functionalised polyketides : application to the preparation of analogues of bioactive natural compounds

Gérald Coste

RNA plays key roles in essential biological processes, such as protein synthesis, transcriptional regulation, splicing and retroviral replication. The structural diversity of RNA molecules and the lack of known RNA repair mechanisms make these biopolymers ...

EPFL2007