Publications related to Sjögren syndrome

Related publications (12)

Discovery of macrocyclic inhibitors of challenging protein-protein interactions

Macrocycles are a therapeutic modality of interest for drugging challenging disease targets due to their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled t ...

EPFL2024

Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea

Alessio Mylonas

Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...

AMER SOC CLINICAL INVESTIGATION INC2023

Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

Jacques Fellay, Christian Axel Wandall Thorball

Objective Primary Sjogren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptom ...

WILEY2022

Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis

Jian Wang, Christian Hammer

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating an autoreactive CD4(+) T cell repertoire is no ...

CELL PRESS2018

Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome

Olaf Blanke, Bruno Herbelin, Andrea Serino, Roberta Ronchi, Javier Bello Ruiz, Marco Solcà, Thomas Schmidlin

OBJECTIVES: To develop and test a new immersive digital technology for complex regional pain syndrome (CRPS) that combines principles from mirror therapy and immersive virtual reality and the latest research from multisensory body processing. METHODS: In t ...

2018

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNF alpha Expression and Empower Adoptive Cell Therapy for Solid Tumors

Melody Swartz

Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such effects could be reprod ...

Amer Assoc Cancer Research2017

Polymeric Anti-HIV Therapeutics

Harm-Anton Klok, Maarten Danial

The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretrovira ...

Wiley-Blackwell2015

Functional Connectivity Eigennetworks Reveal Different Brain Dynamics In Multiple Sclerosis Patients

Dimitri Nestor Alice Van De Ville, Jonas Richiardi, Nora Leonardi

Resting state functional connectivity is defined as correlations in brain activity measured by functional magnetic resonance imaging without any stimulation paradigm. Such connectivity is dynamic, even over the course of minutes, and the development of too ...

Ieee2013

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses

Friedrich Beermann

B-cell-activating factor of the TNF family (BAFF)/BLyS contributes to B-cell homeostasis and function in the periphery. BAFF is expressed as a membrane-bound protein or released by proteolytic cleavage, but the functional importance of this processing even ...

Wiley2011

Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism

Freddy Radtke, Yann Barrandon

Integrity and preservation of a transparent cornea are essential for good vision. The corneal epithelium is stratified and nonkeratinized and is maintained and repaired by corneal stem cells. Here we demonstrate that Notch1 signaling is essential for cell ...

Cell Press - Elsevier2007

Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation

Boris Hinz

We studied the mechanisms underlying the severely impaired wound healing associated with human leukocyte-adhesion deficiency syndrome-1 (LAD1) using a murine disease model. In CD18(-/-) mice, healing of full-thickness wounds was severely delayed during gra ...

Nature Publishing Group2005