Concept

Osteomyelitis

Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying redness, fever, and weakness. The long bones of the arms and legs are most commonly involved in children e.g. the femur and humerus, while the feet, spine, and hips are most commonly involved in adults. The cause is usually a bacterial infection, but rarely can be a fungal infection. It may occur by spread from the blood or from surrounding tissue. Risks for developing osteomyelitis include diabetes, intravenous drug use, prior removal of the spleen, and trauma to the area. Diagnosis is typically suspected based on symptoms and basic laboratory tests as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). This is because plain radiographs are unremarkable in the first few days following acute infection. Diagnosis is further confirmed by blood tests, medical imaging, or bone biopsy. Treatment of bacterial osteomyelitis often involves both antimicrobials and surgery. In people with poor blood flow, amputation may be required. Treatment of the relatively rare fungal osteomyelitis as mycetoma infections entails the use of antifungal medications. In contrast to bacterial osteomyelitis, amputation or large bony resections is more common in neglected fungal osteomyelitis, namely mycetoma, where infections of the foot account for the majority of cases. Treatment outcomes of bacterial osteomyelitis are generally good when the condition has only been present a short time. About 2.4 per 100,000 people are affected each year. The young and old are more commonly affected. Males are more commonly affected than females. The condition was described at least as early as the 300s BC by Hippocrates. Prior to the availability of antibiotics, the risk of death was significant. Symptoms may include pain in a specific bone with overlying redness, fever, and weakness and inability to walk especially in children with acute bacterial osteomyelitis. Onset may be sudden or gradual. Enlarged lymph nodes may be present.

Official source

https://en.wikipedia.org/wiki/Osteomyelitis

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Related publications (6)

Genome-wide association study of paediatric bacteraemia and sepsis

SummaryBackground Sepsis is defined as a dysregulated host response to infection leading to organ dysfunction. It represents a major global health concern, particularly in childhood. The underlying pathophysiological and genetic mechanisms remain insufficiently understood. Methods Using samples and clinical data from 650 children enrolled in the Swiss Pediatric Sepsis Study, a national multicentre cohort for culture-proven bacterial sepsis, we conducted within-cohort analyses and

Elsevier BV2026

Transformer-based structuring of Italian electronic health records with application in cardiac settings

Purpose Natural Language Processing (NLP) has the potential to extract structured clinical knowledge from unstructured Electronic Health Records (EHRs). However, the limited availability of annotated datasets for algorithm training restricts its application in clinical practice. This study investigates the use of transformer-based NLP models to structure Italian EHRs in cardiac settings, addressing this gap. Methods We implemented and evaluated three named entity recognition algorithms: SpaCy, Flair, and Mu

openRxiv2026

Epithelial Reprogramming by OM-89 Enhances Antibiotic Clearance of Uropathogenic E. coli in a Bladder Organoid Model

Recurrent urinary tract infections (UTIs) are a major clinical burden, often driven by the ability of uropathogenic Escherichia coli (UPEC) to persist intracellularly within bladder epithelial cells, protected from antibiotics and host immune responses. While vaccine and antibiotic alternatives are being explored, strategies that enhance epithelial cell-intrinsic defense mechanisms remain sparse. Here, we show that OM-89 (Uro-Vaxom®), an E. coli lysate, reprograms epithelial antimicrobial responses to enhan

Cold Spring Harbor Laboratory2025

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Official source

https://en.wikipedia.org/wiki/Osteomyelitis

About this result

Ontological neighbourhood

Health sciences

Infectious diseases: Pathogenic bacteria

Related publications (6)

Genome-wide association study of paediatric bacteraemia and sepsis

Elsevier BV2026

Transformer-based structuring of Italian electronic health records with application in cardiac settings

openRxiv2026

Epithelial Reprogramming by OM-89 Enhances Antibiotic Clearance of Uropathogenic E. coli in a Bladder Organoid Model

Cold Spring Harbor Laboratory2025

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Positions 2005-now: Research associate, Federal School of Life Sciences, Laboratory of Virology and Genetics, Lausanne, Switzerland 2001-2004: Research associate in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland 1997-2001: Post-doctoral research fellow in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland

Honors and fellowships 2004: Bristol-Myers Squibb AIDS AWARD 1997-1999: Human Frontier Science Program fellowship

Education June 1997: PhD in cellular biology. Final mark:jury congratulations. Université de la Méditerranée, France. June 1993: Post-graduate diploma in cellular biology and microbiology. INSERM U372, Marseille-Luminy, université de Provence, France. June 1992: Master in cellular biology Specialty: genetic. Final mark: Best master student of this year. Université de la Méditerranée, France. June 1987: Scientific baccalaureate, France.

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