Juan Cruz Landoni MartinExpertise
Mitochondria, metabolism, mitochondrial DNA, superresolution microscopy, ageing
Mission
Dissecting the dynamic orchestration between mitochondria and metabolism underlying health, disease and ageing using advanced imaging and integrative multi-omics.
Current Work
I am a chemist turned mitochondria enthusiast. Using molecular biology, super-resolution microscopy and smart imaging techniques, I aim to decipher the complex behaviour of the tiny intruders that live inside our cells, mitochondria, and
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
John BotsisJohn (Ioannis) Botsis obtained his diplôme in civil engineering at the University of Patras, Greece in 1979. He continued his education at Case Institute of Technology in Cleveland Ohio/USA, where he received his MS and Ph.D. in 1984. After two years at the research center for national defense in Athens he was nominated assistant professor at the University of Illinois in Chicago, associate in 1991 and full professor in 1995. In 1996, he was nominated professor of solids and structural mechanics at the EPFL. At EPFL he teaches mechanics of structures and mechanics of continuous media´ at the bachelors level and Fracture mechanics at the masters and doctoral levels. His research covers the mechanics of solids and structures, fracture mechanics and micromechanics of polymers, metals and their composites as well as biomechanics. He is also actively involved in full-filed optical methods for surface strain measurements as well as internal strain measurements using fiber Bragg grating sensors, aimed at characterizing micromechanics of fracture, residual strains and strain distribution in composite laminates for structural monitoring. Funding for his research comes from the Swiss National Science Foundation, State Secretariat for Education and Research and Swiss industry. He retired on February 28, 2020.
Nicolas GrandjeanNicolas Grandjean received a PhD degree in physics from the University ofNice Sophia Antipolis in 1994 and shortly thereafter joined the French National Center for Scientific Research (CNRS) as a permanent staff member. In 2004, he was appointed tenure-track assistant professor at the École polytechnique fédérale de Lausanne (EPFL) where he created the Laboratory for advanced semiconductors for photonics and electronics. He was promoted to full professor in 2009. He was the director of the Institute of Condensed Matter Physics from 2012 to 2016 and then moved to the University of California at Santa Barbara where he spent 6 months as a visiting professor. Since 2018, he is the head of the School of Physics at the EPFL. He was awarded the Sandoz Family Foundation Grant for Academic Promotion, received the “Nakamura Lecturer” Award in 2010, the "Quantum Devices Award” at the 2017 Compound Semiconductor Week, and “2016 best teacher” award from the EPFL Physics School. His research interests are focused on the physics of nanostructures and III-V nitride semiconductor quantum photonics.
Michaël UnserExpertise
Image Processing, Medical Imaging, Biological Imaging, Wavelets, Splines, Multiresolution
Michael Unser is Full Professor with EPFL’s school of Engineering and the academic director of EPFL's Center for Imaging, Lausanne, Switzerland. His primary areas of investigation are signal processing, biomedical imaging and applied functional analysis. He is internationally recognized for his research contributions to sampling theory, wavelets, the use of splines for image processing, stochastic processes,
Daniel SageExpertise
PublicationsPublications
Coordinates Biomedical Imaging GroupAddressEPFL STI-IMT-LIB, BM 4.135, Station 17, CH-1015 Lausanne, SwitzerlandTel.+41 21 693 51 89Fax.+41 21 693 68 10Emaildaniel.sage@epfl.chWeb pagehttp://bigwww.epfl.ch/sage/OfficeBM 4.135
Teaching & PhD Past EPFL PhD Students as codirector Daniel Andreas Schmitter, Anaïs Badoual, Laurène Donati Courses Bioimage informatics BIO-410 The course provides a comprehensive overview of methods, algorithms, and computer tools us Mario PaoloneMario Paolone received the M.Sc. (with honors) and the Ph.D. degree in electrical engineering from the University of Bologna, Italy, in 1998 and 2002, respectively. In 2005, he was appointed assistant professor in power systems at the University of Bologna where he was with the Power Systems laboratory until 2011. In 2010, he received the Associate Professor eligibility from the Politecnico di Milano, Italy. Since 2011 he joined the Swiss Federal Institute of Technology, Lausanne, Switzerland, where he is now Full Professor, Chair of the Distributed Electrical Systems laboratory and Head of the Swiss Competence Center for Energy Research (SCCER) FURIES (Future Swiss Electrical infrastructure). He was co-chairperson of the technical programme committees of the 9th edition of the International Conference of Power Systems Transients (IPST 2009) and of the 2016 Power Systems Computation Conference (PSCC 2016). He was chair of the technical programme committee of the 2018 Power Systems Computation Conference (PSCC 2018). In 2013, he was the recipient of the IEEE EMC Society Technical Achievement Award. He was co-author of several papers that received the following awards: best IEEE Transactions on EMC paper award for the year 2017, in 2014 best paper award at the 13th International Conference on Probabilistic Methods Applied to Power Systems, Durham, UK, in 2013 Basil Papadias best paper award at the 2013 IEEE PowerTech, Grenoble, France, in 2008 best paper award at the International Universities Power Engineering Conference (UPEC). He was the founder Editor-in-Chief of the Elsevier journal Sustainable Energy, Grids and Networks and was Associate Editor of the IEEE Transactions on Industrial Informatics. His research interests are in power systems with particular reference to real-time monitoring and operation, power system protections, power systems dynamics and power system transients. Mario Paolone is author or coauthor of over 300 scientific papers published in reviewed journals and international conferences.
Nadine BalucTeaching & PhD Past EPFL PhD Students Emmanuelle Giacometti, Raluca Schibli, Gang Yu, Bin Long, Lyubomira Veleva
Johan AuwerxJohan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways.
Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards.
Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.
Pierre-Etienne BourbanBackground 1990 Ingénieur en science des matériaux 1993 PhD in materials science Activities 1993-1994 Research at the Center for Composite Materials, University of Delaware, USA (ccm.udel.edu), SNSF grant Since 1994 Research and teaching at EPFL, Composites, (LTC, LPAC) 1995-1999 Coordination Swiss Priority Program on Materials research: 2.2: Composites Since 1998 Biocomposites 2004-2009 Direction of the EPFL Transdisciplinary programme in Sport and Rehabilitation 2005-2008 Member of the EPFL Vice-Presidency for Innovation and Valorisation and direction a.i.EPFL-LTC Since 2016 Direction Discovery Learning Labs Materials/Bioengineering and Engineering
