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Concept

Plasmodium falciparum

Related publications (24)

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

Marc Moniatte, Romain Hamelin, Guillem Dayer

Background: Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes. The cellular functions of Plasmodium falciparum CK2 (PfCK2) are unknown. Th ...

2012

Exploring the Versatility of Cycloplatinated Thiosemicarbazones as Antitumor and Antiparasitic Agents

Paul Joseph Dyson, Catherine Marie Amélie Clavel

Tridentate cycloplatinated thiosemicarbazone complexes have been prepared from a biologically significant ligand, 3,4-dichloroacetophenone thiosemicarbazone (1). The tetranuclear complex 2 was prepared by reaction of the ligand with K-2[PtCl4]. Two mononuc ...

Amer Chemical Soc2012

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

Aurora kinases compose a family of conserved Ser/Thr protein kinases playing essential roles in eukaryotic cell division. To date, Aurora homologues remain uncharacterized in the protozoan phylum Apicomplexa. In malaria parasites, the characterization of A ...

Wiley-Blackwell2011

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

Romain Hamelin, Marc Moniatte

P>Merozoites of malaria parasites invade red blood cells (RBCs), where they multiply by schizogony, undergoing development through ring, trophozoite and schizont stages that are responsible for malaria pathogenesis. Here, we report that a protein kinase-me ...

Wiley-Blackwell2011