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Concept

Folate

Related publications (8)

Vitamin B12 deficiency and impaired expression of amnionless during aging

Albano António De Abreu E Presa De Castro E Sousa

Background Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeleta ...

2018

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Marijana Mionic Ebersold, Débora Bonvin

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability

Heinrich Hofmann, Lionel André Maurizi

A simple, rapid, reproducible, and scalable method for generating highly stable cross-linked superparamagnetic nanohybrids was developed. Pre-coating of superparamagnetic iron oxide nanoparticle surfaces with a biocompatible polymer, hydroxy polyvinyl alco ...

Springer Verlag2017

Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines

Christian Ludwig

Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with sup ...

Informa Healthcare2017

Kinetics of Ultrasonic Drug Delivery from Targeted Micelles

Jeffrey Alan Hubbell

To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug relea ...

Amer Scientific Publishers2015

Investigating the acoustic release of doxorubicin from targeted micelles

Jeffrey Alan Hubbell

The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side ...

Elsevier2013

A vitamin B-12 transporter in Mycobacterium tuberculosis

John McKinney

Vitamin B-12-depende enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B-12 in vitro, it is uncertain whether the org ...

Royal Society, The2013

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Johan Auwerx, Kristina Schoonjans, Taoufiq Harach, Mitsunori Nomura, Thijs Pols, Giuseppe Lo Sasso, Maaike Hélène Oosterveer

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Cell Press2011