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Concept

Catatonia

Related publications (12)

Variability is the rule: Neurophysiology and contextual visual processing in schizophrenia

Dario Alejandro Gordillo Lopez

Traditionally, studies in schizophrenia research employ a single experimental paradigm. The results typically demonstrate a significant difference between patients and controls. Subsequent studies aim to describe the underlying abnormal mechanism at the ge ...

EPFL2024

Identifying Disease-Specific Neural Reactivity to Psychosocial Stress in Borderline Personality Disorder

Dimitri Nestor Alice Van De Ville

BACKGROUND: Patients with borderline personality disorder (BPD) typically present emotion dysregulation (ED) when faced with adversity. However, it is argued that altered stress response may be more influenced by ED than BPD-specific traits. Here, we inves ...

ELSEVIER2022

The shine-through paradigm and the schizophrenia spectrum: a summary

Michael Herzog, Maya Roinishvili, Janir Nuno Ramos Antunes Da Cruz, Ophélie Gladys Favrod, Simona Adele Garobbio

In the past 10 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...

2021

Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton

Emerging evidence has attributed altered network coordination between the default mode, central executive, and salience networks (DMN/CEN/SAL) to disturbances seen in schizophrenia, but little is known for at-risk psychosis stages. Moreover, pinpointing im ...

2020

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Lijing Xin

ious mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneuro ...

2020

Large-Scale Brain Network Dynamics Provide a Measure of Psychosis and Anxiety in 22q11.2 Deletion Syndrome Daniela

Dimitri Nestor Alice Van De Ville, Marie Schaer, Fikret Isik Karahanoglu

BACKGROUND: Prodromal positive psychotic symptoms and anxiety are two strong risk factors for schizophrenia in 22q11.2 deletion syndrome (22q11DS). The analysis of large-scale brain network dynamics during rest is promising to investigate aberrant brain fu ...

ELSEVIER2019

Cortical Dysconnectivity Measured by Structural Covariance Is Associated With the Presence of Psychotic Symptoms in 22q11.2 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Marie Schaer, Maude Schneider

BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is the third-largest known genetic risk factor for the development of psychosis. Dysconnectivity has consistently been implicated in the physiopathology of psychosis. Structural covariance of cortical morphol ...

2018

A novel psychoanalytical approach: An electrochemical ligand-binding assay to screen antipsychotics

Sandro Carrara, Tugba Kilic

Schizophrenia treatment may see a paradigm shift due to development of new atypical antipsychotic drugs (APDs), with better tolerability due to more selective dopamine (DA) receptor blockade. Monitoring of these APD candidates in biological fluids is of gr ...

2018

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Rolf Gruetter, Lijing Xin

Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

Springer Verlag2018

Cortical Interneuron Loss and Symptom Heterogeneity in Huntington Disease

Objective: The cellular basis of variable symptoms in Huntington disease (HD) is unclear. One important possibility is that degeneration of the interneurons in the cerebral cortex, which play a critical role in modulating cortical output to the basal gangl ...

Wiley-Blackwell2014

Reduced Fronto-Temporal and Limbic Connectivity in the 22q11.2 Deletion Syndrome: Vulnerability Markers for Developing Schizophrenia?

Jean-Philippe Thiran, Leila Cammoun, Leila Faiza Ben Hamida Cammoun, Marie Schaer

The 22q11.2 deletion syndrome (22q11DS) is a widely recognized genetic model allowing the study of neuroanatomicalvbiomarkers that underlie the risk for developing schizophrenia. Recent advances in magnetic resonance image analysesvenable the examination o ...

Public Library of Science2013

Dysconnection Topography in Schizophrenia Revealed with State-Space Analysis of EEG

Reto Meuli, Martin Hasler, Oscar De Feo, Mahdi Jalili

Background The dysconnection hypothesis has been proposed to account for pathophysiological mechanisms underlying schizophrenia. Widespread structural changes suggesting abnormal connectivity in schizophrenia have been imaged. A functional counterpart of t ...

2007