Concept

Respiratory epithelium

Related publications (24)

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Mauro Delorenzi, Michel Aguet, Andreas Eduard Moor, Norbert Wiedemann, Patrick Rodriguez

BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...

Elsevier Science Bv2015

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

Freddy Radtke

Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain un ...

Wiley-Blackwell2013

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Juan Camilo Paredes Escobar

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013

Role of Bcl9 and Bcl9l in Homeostasis, Regeneration and Tumorigenesis of the Gastrointestinal Epithelium

Norbert Wiedemann

Wnt signaling is essential for embryogenesis and adult tissue homeostasis and contributes to cancer development, especially in the colon. A new essential pathway component, legless, was identified in Drosophila melanogaster. Mice with Cre/loxP-mediated con ...

EPFL2011