Alpha-2 adrenergic receptor

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Objective: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that is commonly treated with stimulants like methylphenidate. In addition to attentional, hyperactive and impulsive symptoms, cognitive functions like response inhibition are commonly affected in ADHD. Methylphenidate effectively alleviates these symptoms by inhibiting the dopamine and noradrenaline transporters (DAT/NET) in the brain, leading to increased extracellular dopamine and noradrenaline level

Procoagulant platelets play a major role in stabilizing the primary hemostatic plug formed by aggregated platelets. The intracellular signaling pathways driving the shift from an aggregatory to a procoagulant COAT platelet phenotype upon collagen plus thrombin stimulation are only partially elucidated. Aiming at identifying differentially phosphorylated proteins and potential regulators of the procoagulant response, we mapped time-dependent changes in the phosphoproteome of aggregatory vs procoagulant COAT

Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...

Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...

G protein-coupled receptors are recognized as one of the largest families of membrane proteins. Despite sharing a characteristic seven-transmembrane topology, G protein-coupled receptors regulate a wide range of cellular signaling pathways in response to v ...

Emotional face processing is critically modulated by the serotonergic system. For instance, emotional face processing is impaired by acute psilocybin administration, a serotonin (5-HT) 1A and 2A receptor agonist. However, the spatiotemporal brain mechanisms underlying these modulations are poorly understood. Here, we investigated the spatiotemporal brain dynamics underlying psilocybin-induced modulations during emotional face processing. Electrical neuroimaging analyses were applied to visual evoked potenti

Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. The cannabinoid system might regulate peripheral mechanisms of sexual function; ...

Alpha-2 adrenergic receptor

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Effects of methylphenidate on receptor-enriched functional connectivity and the relation with response inhibition in children and adults with attention-deficit/hyperactivity disorder

Temporal phosphoproteomics reveals key regulators of procoagulant COAT platelet generation

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

The Principles of Ligand Specificity on beta-2-adrenergic receptor

Spatiotemporal Brain Dynamics of Emotional Face Processing Modulations Induced by the Serotonin 1A/2A Receptor Agonist Psilocybin

Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice