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Concept

Self-replicating spacecraft

Related publications (26)

Advancing Cell-Free Synthetic Biology: From sustained PURE protein synthesis to an isothermal one-pot DNA replication system

Laura Sophie Grasemann

One of the goals of synthetic biology is the development of an artificial cell. Building an artificial cell from scratch will provide a deeper understanding of fundamental mechanisms and models in biology and promises to contribute towards building novel p ...

EPFL2024

Planetary-Scale Byzantine Fault Tolerance

Matteo Monti

The scale and pervasiveness of the Internet make it a pillar of planetary communication, industry and economy, as well as a fundamental medium for public discourse and democratic engagement. In stark contrast with the Internet's decentralized infrastructur ...

EPFL2024

uBFT: Microsecond-Scale BFT using Disaggregated Memory

Rachid Guerraoui, Mihail Igor Zablotchi, Athanasios Xygkis, Antoine Murat

We propose uBFT, the first State Machine Replication (SMR) system to achieve microsecond-scale latency in data centers, while using only 2f+1 replicas to tolerate f Byzantine failures. The Byzantine Fault Tolerance (BFT) provided by uBFT is essential as pu ...

2023

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

Barbora Lavickova

Thanks to recent advancements in synthetic biology, the dream of creating a synthetic cell has become feasible. However, due to its inherent complexity, one of the fundamental functions of all living systems, i.e., self-replication, remains to be introduce ...

EPFL2021

Replicated state machines without replicated execution

Kirill Nikitin

This paper introduces a new approach to reduce end-to-end costs in large-scale replicated systems built under a Byzantine fault model. Specifically, our approach transforms a given replicated state machine (RSM) to another RSM where nodes incur lower costs ...

IEEE2020

System Support for Efficient Replication in Distributed Systems

Dragos-Adrian Seredinschi

Current online applications, such as search engines, social networks, or file sharing services, execute across a distributed network of machines. They provide non-stop services to their users despite failures in the underlying network. To achieve such a hi ...

EPFL2019

Nanostructured surface topographies have an effect on bactericidal activity

Jürgen Brugger, Songmei Wu

Background Due to the increased emergence of antimicrobial resistance, alternatives to minimize the usage of antibiotics become attractive solutions. Biophysical manipulation of material surface topography to prevent bacterial adhesion is one promising app ...

2018

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri

During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a series of chemical and morphological modifications, which include devia ...

2018

Mask-aligner Talbot lithography using a 193 nm CW light source

Toralf Scharf, Wilfried Noell, Raoul Kirner

We present and discuss Talbot mask-aligner lithography, relying on a continuous wave laser emitting at 193nm for the illumination. In this source, a diode laser at 772nm is amplified by a tapered amplifier in master-oscillator power-amplifier configuration ...

2018

On the Limits of Precision Glass Molding for Diffractive Optical Elements

Karin Prater

Diffractive optical elements (DOEs) consist of surface reliefs with dimensions in the micrometer range and nanometer precision. Two technologies dominate: Elements replicated in plastic and directly microfabricated elements in fused silica. Plastic DOEs ar ...

EPFL2017

New 1-hydroxy-2-thiopyridine derivatives active against both replicating and dormant Mycobacterium tuberculosis

Stewart Cole, Anthony Vocat

Tuberculosis (TB) treatment is confounded by the range of metabolic states displayed by Mycobacterium tuberculosis, by the long duration required and by the increasing prevalence of drug-resistant strains. Latent TB infection is especially difficult to tre ...

Elsevier Science Bv2017

Precision glass molding of high-resolution diffractive optical elements

Hans Peter Herzig, Toralf Scharf, Karin Prater

The demand of high resolution diffractive optical elements (DOE) is growing. Smaller critical dimensions allow higher deflection angles and can fulfill more demanding requirements, which can only be met by using electron-beam lithography. Replication techn ...

Spie-Int Soc Optical Engineering2016

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

Stewart Cole, Ruben Hartkoorn

Whole cell based screens to identify hits against Mycobacterium tuberculosis (Mtb), carried out under replicating and non-replicating (NRP) conditions, resulted in the identification of multiple, novel but structurally related spiropiperidines with potent ...

Elsevier2015

Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis

Stewart Cole, Anthony Vocat, Ruben Hartkoorn

The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis highlights the need to discover new antitubercular agents. Here we describe the synthesis and characterization of a new series of thienopyrimidine (TP) compoun ...

American Chemical Society2014

A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria

John McKinney, Giulia Manina

A long-standing and fundamental problem in microbiology is the non-trivial discrimination between live and dead cells. The existence of physically intact and possibly viable bacterial cells that fail to replicate during a more or less protracted period of ...

Springer-Verlag2014

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Mélanie Craveiro, Philippe Guillaume Coune, Meret Gaugler

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

A class of Neumann type systems and its application

A class of Neumann type systems are derived separating the spatial and temporal variables for the 2+1 dimensional Caudrey-Dodd-Gibbon-Kotera-Sawada (CDGKS) equation and the modified Korteweg-de Vries (mKdV) hierarchy. The Lax-Moser matrix of Neumann type s ...

International Press2012

A High-Throughput Byzantine Fault-Tolerant Protocol

Nikola Knezevic

State-machine replication (SMR) is a software technique for tolerating failures and for providing high availability in large-scale systems, through the use of commodity hardware. A replicated state-machine comprises a number of replicas, each of which runs ...

EPFL2012

State Machine Replication : from Analytical Evaluation to High-Performance Paxos

Nuno Filipe de Sousa Santos

Since their invention more than half a century ago, computers have gone from being just an handful of expensive machines each filling an entire room, to being an integral part of almost every aspect of modern life. Nowadays computers are everywhere: in our ...

EPFL2012

From Data and Signals Cellular Automata to Self-organizing Circuits

Joël Rossier

Self-organizing circuits are able to grow, to self-replicate, and to self-repair. These properties are implemented in hardware thanks to configuration, cloning and cicatrization mechanisms. They are realized by the configuration layer of the POEtic tissue, ...

Springer-Verlag New York, Ms Ingrid Cunningham, 175 Fifth Ave, New York, Ny 10010 Usa2008