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Concept

Vertebra

Related publications (18)

Fatigue behavior of transverse attachments under constant and variable amplitude loading from a Swiss motorway bridge

Alain Nussbaumer

This paper investigates the fatigue behavior of non-load-carrying transverse welded steel attachments by reporting on an experimental characterization under constant and variable amplitude loading. Fatigue cracks have been monitored using DIC and ACPD tech ...

Elsevier Sci Ltd2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo, Theofanis Stampoultzis

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord

Ihor Kuras

The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...

EPFL2023

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

2021

Lumbar and thoracic kinematics during step-up: Comparison of three-dimensional angles between patients with chronic low back pain and asymptomatic individuals

Julien Favre, Brigitte Jolles-Haeberli

While alterations in spinal kinematics have been repeatedly observed in patients with chronic low back pain (CLBP), their exact nature is still unknown. Specifically, there is a need for comprehensive assessments of multisegment spinal angles during daily- ...

2020

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Dominique Pioletti, Pierre-Etienne Bourban, Baris Çaglar, Azadeh Khoushabi, Céline Samira Wyss

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacryl ...

2018

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Susanne Petra Pfeifer

Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mou ...

Wiley2017

Chronic low back pain patients walk with locally altered spinal kinematics

Julien Favre, Brigitte Jolles-Haeberli

Various studies have reported alterations of spinal kinematics in patients with chronic low back pain (CLBP) during gait. However, while recent findings stressed the importance of multi-segment analysis, most of prior gait studies modelled the lumbar spine ...

Elsevier Sci Ltd2017

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

Julien Favre

While alterations in spinal kinematics have been frequently reported in patients with chronic low back pain (CLBP), a better characterization of the kinematics during functional activities is needed to improve our understanding and therapeutic solutions fo ...

Elsevier Sci Ltd2016

Surgical probe and implant development for nucleus pulposus replacements

Andreas Schmocker

Intervertebral disc degeneration is a major reason why we experience low back pain. Intervertebral discs are located in-between the vertebrae of the spine. They act, among other, as shock absorbers by distributing the mechanical load applied to the spine w ...

EPFL2016

A statistical shape model of the human second cervical vertebra

Reto Meuli, Simon Nessim Henein, Charles Baur, Marine Chantal Elisabeth Geneviève Clogenson

Statistical shape and appearance models play an important role in reducing the segmentation processing time of a vertebra and in improving results for 3D model development. Here, we describe the different steps in generating a statistical shape model (SSM) ...

Springer Heidelberg2015

Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine

Denis Duboule

Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thor ...

National Academy of Sciences2013

Objective evaluation of cervical spine mobility after surgery during freeliving activity

Kamiar Aminian, Cyntia Duc

Background: Evaluation of cervical spine mobility after surgery is mainly based on the measurement of the range of motion during imposed movements. It can thus be questionable if this assessment represents the mobility experienced during daily life. The go ...

Elsevier Sci Ltd2013

Robotic system for cervical spine surgery

Charles Baur

Background In contemporary surgical clinical practice, spinal instability is often treated with mechanical stabilization techniques in order to protect the spinal cord and nerve roots. These techniques involve placing screws in defined regions of the verte ...

2012

Biocomposite Hydrogels with Carboxymethylated, Nanofibrillated Cellulose Powder for Replacement of the Nucleus Pulposus

Jan-Anders Edvin Maansson, Pierre-Etienne Bourban, Ana Borges de Couraça, Fabien Duc

Biocomposite hydrogels with carboxymethylated, nanofibrillated cellulose (c-NFC) powder were prepared by UV polymerization of N-vinyl-2-pyrrolidone with Tween 20 trimethacrylate as a cross-linking agent for replacement of the native, human nucleus pulposus ...

American Chemical Society2011

Thermomechanical Hysteresis of Biological and Synthetic Hydrogels : Theory, Characterisation, and Development of a Novel Deformation Calorimeter

Arne Christian Vogel

The nucleus pulposus of the intervertebral disc is a gelatinous viscous hydrogel that has an essential role in the mechanics of the intervertebral disc joint. The viscoelastic properties of the nucleus pulposus significantly change in the course of time an ...

EPFL2011

Composite Hydrogels for the Replacement of the Nucleus Pulposus

Ana Borges de Couraça

The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the N ...

EPFL2010

Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories

Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pr ...

2010