Concept

Holliday junction

Related publications (6)

Scanning ion-conductance spectroscopy and force microscopy of biomolecules

Single-molecule sensors have found widespread applications in probing biological processes at the fundamental scale and enabling detection at the ultimate sensitivity limit. In this work, a Scanning Ion Conductance Microscope (SICM) system is presented as a platform for single-molecule sensing and as a tool capable of extracting physical properties, such as stiffness. This thesis is divided into two parts. The first part of the thesis focuses on the use of the Scanning Ion Conductance Spectroscopy (SICS) m

EPFL2026

Programing Crystal Growth with DNA Tile Seeds

Nucleation and crystal growth underpin the formation of ordered structures from disordered systems, yet spontaneous nucleation is inherently stochastic and difficult to control. Seeding can introduce preformed nuclei to guide assembly, which offers a strategy to regulate these processes. Here, we investigate seeded nucleation in the two‐dimensional assembly of trimeric macromolecules using programable DNA tiles as a model system. Introducing a single DNA tile as a nucleation seed enabled size‐ and shape‐con

Wiley2026

Mouse lemur cell atlas informs primate genes, physiology and disease

Mouse lemurs (Microcebus spp.) are an emerging primate model organism, but their genetics, cellular and molecular biology remain largely unexplored. In an accompanying paper1, we performed large-scale single-cell RNA sequencing of 27 organs from mouse lemurs. We identified more than 750 molecular cell types, characterized their transcriptomic profiles and provided insight into primate evolution of cell types. Here we use the generated atlas to characterize mouse lemur genes, physiology, disease and mutation

2025

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Christian Iseli, Nicolas Mermod, Thomas Junier

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous r ...

2017

Impact of Cable Twist Pitch on T-cs-Degradation and AC Loss in Nb3Sn Conductors for ITER Central Solenoids

Pierluigi Bruzzone, Kamil Sedlák, Boris Stepanov

The performance of tour Nb3Sn conductors for the ITER central solenoids was tested. The current sharing temperatures (T-cs) were measured over approximately 9000 electromagnetic cycles, including two or three thermal cycles between 4.2 K and room temperatu ...

IEEE Institute of Electrical and Electronics Engineers2014

The voltage/current characteristic (n index) of the cable-in-conduit conductors for fusion

Pierluigi Bruzzone, Rainer Wesche, Boris Stepanov

The index n of the voltage-current characteristic of large superconductors is a crucial parameter to assess the allowed range for coil operation. In the tests of the Insert coils at the CSMC as well as in the short sample test in the SULTAN facility, it is observed that the index n dramatically decreases from the Nb3Sn strands extracted from cable-in-conduit provide the evidence of a permanent performance drop in the strands, likely due to the transverse load accumulation at the strand crossovers in the cab

IEEE Institute of Electrical and Electronics Engineers2003

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