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Concept

Biological activity

Related publications (27)

Bioavailability of inorganic nanoparticles to planktonic bacteria and aquatic microalgae in freshwater

Paul Bowen, Nadia Rachel Von Moos

Over the past few years, engineered nanomaterials (ENMs) have penetrated nearly every sector of modern life and their broad-scale use is steadily and rapidly increasing. The (expected) elevated levels of ENMs in the environment raise concerns with regard t ...

Royal Soc Chemistry2014

Characterization of Three Amino-Functionalized Surfaces and Evaluation of Antibody Immobilization for the Multiplex Detection of Tumor Markers Involved in Colorectal Cancer

Vincent Laporte, Nicolas Xanthopoulos

Antibody microarrays are powerful and high-throughput tools for screening and identifying tumor markers from small sample volumes of only a few microliters. Optimization of surface chemistry and spotting conditions are crucial parameters to enhance antibod ...

Amer Chemical Soc2013

MQN-Mapplet: Visualization of Chemical Space with Interactive Maps of Drug Bank, ChEMBL, Pub Chem, GDB-11, and GDB-13

The MQN-mapplet is a Java application giving access to the structure of small molecules in large databases via color-coded maps of their chemical space. These maps are projections from a 42-dimensional property space defined by 42 integer value descriptors ...

Amer Chemical Soc2013

The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics

Paul Joseph Dyson, Angela Casini

DIGE (difference in gel electrophoresis) proteomics is exploited here to gain insight into the molecular mechanisms of two established ruthenium-based antimetastatic agents, namely trans-[tetrachloro (DMSO) (imidazole)ruthenate(III)] (NAMI-A) and [Ru(eta(6 ...

Elsevier Science Inc2013

A new target for gold(I) compounds: glutathione-S.transferase inhibition by auranofin

Paul Joseph Dyson, Christian Hartinger, Angela Casini

Nowadays, gold compounds occupy a relevant position constituting a promising class of experimental anticancer metallodrugs. Several research efforts have been devoted to the investigations of the pharmacological properties of gold(I) complexes bearing phos ...

Elsevier Science Inc2013

Electrochemical Detection of Anti-Breast-Cancer Agents in Human Serum by Cytochrome P450-Coated Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi

We report on the electrochemical detection of anti-cancer drugs in human serum with sensitivity values in the range of 8–925 nA/µM. Multi-walled carbon nanotubes were functionalized with three different cytochrome P450 isoforms (CYP1A2, CYP2B6, and CYP3A4) ...

2012

Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch

Organic small molecules are of particular interest for medicinal chemistry since they comprise many biologically active compounds which are potential drugs. To understand this vast chemical space, we are enumerating all possible organic molecules to create ...

2011