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Concept

Artificial induction of immunity

Related publications (28)

Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead

Nicola Harris

The rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host–parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became ...

Wiley-Blackwell2014

Engineering synthetic vaccines using cues from natural immunity

Melody Swartz

Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attac ...

Nature Publishing Group2013

Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclonal Antibodies and the Identification of T-Cell-Activating Peptides

Matteo Dal Peraro

Defining immunogenic domains of viral proteins capable of eliciting a protective immune response is crucial in the development of novel epitope-based prophylactic strategies. This is particularly important for the selective targeting of conserved regions s ...

Hindawi Publishing Corporation2013

Brillouin distributed fibre sensing using phase modulated probe

Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Xin Lu

A novel configuration for a Brillouin distributed sensor using a phase modulated probe is presented. It offers the combined advantages of a direct implementation using simple devices and a large immunity to noise, shifting the information from the baseband ...

Spie-Int Soc Optical Engineering2013

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles

Jeffrey Alan Hubbell, Melody Swartz

Using poly(propylene sulfide) (PPS) and poly(ethylene glycol) (PEG) as components of a nanocarrier platform, we sought to compare immune responses induced by PPS-bl-PEG polymersomes (PSs; watery-core structures, with antigen incorporated within the PSs) an ...

Elsevier Sci Ltd2013

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

Nicola Harris, Mario Michael Zaiss, Ilaria Mosconi

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution ...

Public Library Science2013

Antibodies and IL-3 support helminth-induced basophil expansion

Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Tina Herbst, Manuel Kulagin

Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknow ...

National Academy of Sciences2012

Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization

Jeffrey Alan Hubbell, Melody Swartz

Background: The development of nanoparticulate antigen-delivery systems is an important emerging area of vaccinology, being sought to amplify immune responses to recombinant antigens that are poorly immunogenic. Nanoparticle size may play an important role ...

Elsevier2012