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Concept

Blood bank

Related publications (31)

Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging

Pierre Marquet, Gerardo Turcatti, Benjamin Rappaz, Michel Prudent, Manon Sandra Bardyn

We propose methods to quantitatively calculate the fluctuation rate of red blood cells with nanometric axial and millisecond temporal sensitivity at the single-cell level by using time-lapse holographic cell imaging. For this quantitative analysis, cell me ...

2018

Towards Elucidating the Mechanism of Action of Biguanides

Nicolas Peter Goeldel

Diabetes type 2 patients are insensitive to insulin, a condition that leads to reduced glucose uptake by cells and, subsequently, to high concentration of glucose in the blood. For 60 years, biguanides have been one of the few effective therapeutics in red ...

EPFL2018

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Vitamin B12 deficiency and impaired expression of amnionless during aging

Albano António De Abreu E Presa De Castro E Sousa

Background Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeleta ...

2018

Microdevice for Sedimentation-based Separation of Blood Microsamples at the Point of Collection

David Forchelet

Laboratory blood testing plays a central role in current diagnostics and therapeutical decisions. Thus, errors have a direct impact on care quality and cost. The majority of errors occur in the pre-analytical phase, when samples are collected, stored and p ...

EPFL2017

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment

Heinrich Hofmann, Duncan Thomas Lindsay Alexander, Marc Moniatte, Marijana Mionic Ebersold, Débora Bonvin, Ulrich Aschauer, Diego Chiappe

In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hen ...

Wiley-Blackwell2017

Red blood cells ageing markers: a multi-parametric analysis

Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, Michel Prudent, Manon Sandra Bardyn

Background. Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 degrees C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells ac ...

Simti Servizi Srl2017

Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo

Sarah Catherine Sonnay

Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...

EPFL2017

Osmolarity: A hidden factor in Nanotoxicology

Omid Mashinchian

In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stre ...

Biomed Central Ltd2016

Sensitive and fast identification of bacteria in blood samples by immunoaffinity mass spectrometry for quick BSI diagnosis

Hubert Girault, Horst Pick, Liang Qiao, Natalia Gasilova, Alexandra Bondarenko, Niels Erik Lion, Michel Prudent, Yingdi Zhu

Bloodstream infections rank among the most serious causes of morbidity and mortality in hospitalized patients, partly due to the long period (up to one week) required for clinical diagnosis. In this work, we have developed a sensitive method to quickly and ...

Royal Soc Chemistry2016

Modelling of a Dielectric Electroactive Polymer Tubular Shape Sensor for Pressure Measurements

Yves Perriard, Yoan René Cyrille Civet, Jonathan André Jean-Marie Chavanne

The variation of pressure of the blood is a key parameter in the development of ventricular assist device. This latter is useful in order to synchronize the behavior of the actuator with the cardiac frequency. This paper presents a sensor made of a dielect ...

IEEE2016