Monomeric phthalocyanine pentylester derivatives containing Cu and Zn were synthesized via the cyclotetramerization of 4,5-dipentylphthalonitrile. Conversion of the pentylester derivatives by hydrolysis yielded the octacarboxylic acid phthalocyanine deriva ...
A new target in AIDS therapy development is HIV-1 integrase (IN). It was proven that HIV-1 IN required divalent metal cations to achieve phosphodiester bond cleavage of DNA. Accordingly, all newly investigated potent IN inhibitors contain chemical fragment ...