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Concept

Epigenetic clock

Related publications (29)

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Elisa Oricchio, Elena Battistello, Stephanie Jocelyne Sungalee, Natalya Katanayeva, Maria Christine Donaldson

Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18), frequent losses of chromosome 6q, and mutations in epigenetic regulators such as EZH2 Using a focu ...

American Association for the Advancement of Science2017

Stability against backward balance loss: Age-related modifications following slip-like perturbations of multiple amplitudes

Silvestro Micera

Falls are one of the most serious problems in the elderly. Although previous studies clearly link the increased risk of falls with ageing, the mechanisms responsible for the modifications of reactive motor behaviours in response to external perturbations a ...

Elsevier Ireland Ltd2017

Quantitative telomeric chromatin isolation protocol for human cells

Joachim Lingner, Jana Majerská, Sophie Redon

The ends of eukaryotic chromosomes, known as telomeres, consist of repetitive DNA sequences, multiple proteins and noncoding RNAs. Telomeres are dynamic structures that play crucial roles as guardians of genome stability and tumor suppressors. Defects in t ...

2017

Mitochondria and Epigenetics Crosstalk in Homeostasis and Stress

Johan Auwerx

Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene expression levels. Mitochondrial function is essential to provide the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, which in ...

Elsevier Science London2017

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Rolf Gruetter, Ana Francisca Leal Silva Soares, Hongxia Lei, Marc Moniatte, Jonathan Paz Montoya

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

Wiley-Blackwell2017

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Johan Auwerx, Laurent Mouchiroud, Evan Graehl Williams, Virginija Jovaisaite

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeost ...

Cell Press2016

Mitochondrial unfolded protein response, its molecular mechanism and physiological impact

Virginija Jovaisaite

Mitochondria are the main producers of ATP, the energy currency of the cell, and they perform a wide array of other fundamental functions. These organelles are essential not only for cellular metabolism, but also for organismal physiology and lifespan. A r ...

EPFL2016

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

Kristin Schirmer, Yang Yue

While short-term exposures of vertebrate cells, such as from fish, can be performed in defined, serum-free media, long-term cultures generally require addition of growth factors and proteins, normally supplied with a serum supplement. However, proteins are ...

Taylor & Francis Ltd2016

An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits

Nicolas Lonfat

Coordinated expression of HoxD cluster genes is crucial for the emergence and patterning of both developing digits and external genitalia. As a shared evolutionary origin has been proposed for these secondary structures, which may have accompanied the tran ...

EPFL2013