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Concept

Purkinje fibers

Related publications (16)

Towards an in vitro cardiac model: 3D environment, co-culture, alignment, and mechanical stimulation impact on cell behavior

Fatemeh Navaee

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

EPFL2021

Soft functional fibers for mechanical sensing and actuation

Andreas Leber

The measurement and generation of mechanical deformations is a key functionality in health monitoring, human-machine interaction, and soft robotics. However, current methods typically rely on small and hard transducers, which result in poor performance, cu ...

EPFL2021

Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation

Philippe Renaud, Arnaud Bertsch, Nicolas Grégoire Maïno, Benoît Xavier Emmanuel Desbiolles

Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...

2020

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Henry Markram, Rajnish Ranjan, Emmanuelle Logette, Enrico Scantamburlo, Michela Marani, Valérie Buchillier, Mirjia Herzog

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

2019

Compressible and Electrically Conducting Fibers for Large‐Area Sensing of Pressures

Pedro Miguel Nunes Pereira de Almeida Reis, Fabien Sorin, Alexis Gérald Page, Yunpeng Qu, Andreas Leber, Dong Yan, Shahrzad Shadman Yazdi

Flexible pressure sensors offer a wide application range in health monitoring and human–machine interaction. However, their implementation in functional textiles and wearable electronics is limited because existing devices are usually small, 0D elements, a ...

2019

Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia

João Miguel das Neves Duarte, Rolf Gruetter, Yohan Van de Looij, Alberto Corcoba

BACKGROUND: Structural anomalies of white matter (WM) are found in various brain regions of patients with schizophrenia, bipolar and other psychiatric disorders, but the causes at cellular and molecular levels remain unclear. Oxidative stress and redox dys ...

Oxford Univ Press2016

A coupled 3D-1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network

Alfio Quarteroni, Christian Vergara, Toni Mikael Lassila

We present a model for the electrophysiology in the heart to handle the electrical propagation through the Purkinje system and in the myocardium, with two-way coupling at the Purkinje-muscle junctions. In both the subproblems the monodomain model is consid ...

Elsevier2016

On the Firing Rate Dependency of the Phase Response Curve of Rat Purkinje Neurons In Vitro

Michele Giugliano

Synchronous spiking during cerebellar tasks has been observed across Purkinje cells: however, little is known about the intrinsic cellular mechanisms responsible for its initiation, cessation and stability. The Phase Response Curve (PRC), a simple input-ou ...

Public Library Science2015

Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws

Alfio Quarteroni, Simone Deparis, Luca Dede', Paolo Tricerri

This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...

Springer Verlag2015

Patient-specific generation of the Purkinje network driven by clinical measurements of a normal propagation

Alfio Quarteroni, Fabio Nobile, Christian Vergara, Elena Faggiano

The propagation of the electrical signal in the Purkinje network is the starting point for the activation of the ventricular muscular cells leading to the contraction of the ventricle. In the computational models, describing the electrical activity of the ...

Springer Verlag2014

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Michaël Unser, Nikolaos Stergiopoulos, Alessandra Griffa, Daniel Sage, Aristotelis Agianniotis, Jelle Tymen Christiaan Schrauwen

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Active strain and activation models in cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi

We present a model for mechanical activation of the cardiac tissue depending on the evolution of the transmembrane electrical potential and certain gating/ionic variables that are available in most of electrophysiological descriptions of the cardiac membra ...

2011

Metal Ion Implantation for the Fabrication of Stretchable Electrodes on Elastomers

Herbert Shea, Samuel Rosset, Muhamed Niklaus

We report on low-energy metal ion implantation by filtered cathodic vacuum arc to create highly deformable electrodes on polydimethylsiloxane (PDMS) membranes. Implantation leads to the creation of nanometer-size clusters in the first 50 nm below the surfa ...

Wiley-Blackwell2009

A structure-based model of arterial remodeling in response to sustained hypertension

Nikolaos Stergiopoulos, Alexander Rachev

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

Mechanical orchestration of tissue remodeling

After organ injury, a complex sequence of events is triggered to heal the tissue and to form a scar. Myofibroblasts, specialized contractile and secretory fibroblasts, are one of the many cell types that participate in the remodeling process. Myofibroblast ...

EPFL2008

Structural strain energy function applied to the ageing of the human aorta

Nikolaos Stergiopoulos, Martin Zulliger

Stiffening of the aorta with progressing age leads to decrease of aortic compliance and thus to an increase of pulse pressure amplitude. Using a strain energy function (SEF) which takes into account the composition of the arterial wall, we have studied the ...

2007