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Concept

Lung

Related publications (31)

Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes

Sina Nassiri, Nahal Mansouri

Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects of extracellular vesicles produced by human BM MSCs (MEx) in a bleomycin- ...

AMER SOC CLINICAL INVESTIGATION INC2019

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

Paul Joseph Dyson, Gerardo Turcatti, Fabien Kuttler, Damiano Banfi, Hristo Plamenov Varbanov

Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...

2019

FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components

Lalit Kumar Dubey

Aspergillus fumigatus (A. fumigatus) is a ubiquitous fungus of clinical importance associated with development of various pulmonary diseases and allergic hypersensitivity reactions. It is protected against environmental stress by a cell wall that contains ...

FRONTIERS MEDIA SA2018

Automated computer-assisted quantitative analysis of intact murine lungs at the alveolar scale

Goran Lovric

Using state-of-the-art X-ray tomographic microscopy we can image lung tissue in three dimensions in intact animals down to a micrometer precision. The structural complexity and hierarchical branching scheme of the lung at this level of details, however, re ...

Public Library of Science2017

Tomographic in vivo microscopy for the study of lung physiology at the alveolar level

Goran Lovric

Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations o ...

Nature Research2017

Effective segmentation of fresh post-mortem murine lung parenchyma in phase contrast X-ray tomographic microscopy images

Goran Lovric

The acinus represents the functional unit of the mammalian lung. It is defined as the small tree of gas-exchanging airways, which is fed by the most distal purely conducting airway. Different hypotheses exist on how the fine structure of the acinus changes ...

Iop Publishing Ltd2017

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Cathrin Brisken, Stéphanie Cagnet

AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...

Company of Biologists2017

An original valveless artificial heart providing pulsatile flow tested in mock circulatory loops

François Avellan, Audrey Paulette Solange Maertens

Purpose: We present the test bench results of a valveless total artificial heart that is potentially compatible with the pediatric population. Methods: The RollingHeart is a valveless volumetric pump generating pulsatile flow. It consists of a single spher ...

Wichtig Editore2017

Increased Myeloid Cell Production and Lung Bacterial Clearance in Mice Exposed to Cigarette Smoke

Alessandra Piersigilli

Pneumonia is a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD). Although most patients with COPD are smokers, the effects of cigarette smoke exposure on clearance of lung bacterial pathogens and on immune and ...

Amer Thoracic Soc2016

Effect of pool confinement on pressures around a block impacted by plunging aerated jets

Anton Schleiss, Rafael Xavier Meriade Duarte

The erosion caused by jets issued from hydraulic structures progressively develops a confined scour-hole on the riverbed. A realistic scour assessment must consider both the influence of the air entrained when the jet plunges into the pool and the flow pat ...

National Research Council Canada2016

A 3-D Riesz-Covariance Texture Model for Prediction of Nodule Recurrence in Lung CT

Adrien Raphaël Depeursinge

This paper proposes a novel imaging biomarker of lung cancer relapse from 3-D texture analysis of CT images. Three-dimensional morphological nodular tissue properties are described in terms of 3-D Riesz-wavelets. The responses of the latter are aggregated ...

Institute of Electrical and Electronics Engineers2016