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Concept

Left bundle branch block

Related publications (27)

Hemodynamic effects of a dielectric elastomer augmented aorta on aortic wave intensity: An in-vivo study

Yves Perriard, Yoan René Cyrille Civet, Thomas Guillaume Martinez, Armando Matthieu Walter, Francesco Clavica, Silje Ekroll Jahren

Dielectric elastomer actuator augmented aorta (DEA) represents a novel approach with high potential for assisting a failing heart. The soft tubular device replaces a section of the aorta and increases its diameter when activated. The hemodynamic interactio ...

2023

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Francesco Regazzoni, Christian Vergara

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Nikolaos Stergiopoulos

The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the markers ...

MDPI2023

Efficient approximation of cardiac mechanics through reduced-order modeling with deep learning-based operator approximation

Alfio Quarteroni, Andrea Manzoni

Reducing the computational time required by high-fidelity, full-order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. Indeed, while FOMs, such as th ...

Wiley2023

Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation

Anna Mary Mc Cann

Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...

EPFL2023

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice

Analina Raquel Hausin

The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become pro-tective against several pathologies, including card ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Design and modelling of a tubular dielectric elastomer actuator with constrained radial displacement as a cardiac assist device

Yves Perriard, Yoan René Cyrille Civet, Jonathan André Jean-Marie Chavanne, Armando Matthieu Walter

In this paper, we propose an improvement of a dielectric elastomer actuator (DEA) based augmented aorta. The actuator is a multi-layered tubular DEA subject to the internal pressure of the blood. When activated in synchronisation with the heart, the DEA su ...

IOP PUBLISHING LTD2021

Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation

Jean-Marc Vesin, Etienne Pruvot, Andréa Buttu, Adrian Luca

Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent ...

2021

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Alfio Quarteroni, Luca Dede', Christian Vergara

Systolic Anterior Motion (SAM) of the mitral valve - often associated with Hypertrophic Obstructive Cardiomyopathy (HOCM) - is a cardiac pathology in which a functional subaortic stenosis is induced during systole by the mitral leaflets partially obstructi ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Severe and uniform bi-atrial remodeling measured by dominant frequency analysis in persistent atrial fibrillation unresponsive to ablation

Jean-Marc Vesin, Etienne Pruvot, Andréa Buttu, Adrian Luca

Background High values of ECG and intracardiac dominant frequency (DF) are indicative of significant atrial remodeling in persistent atrial fibrillation (peAF). We hypothesized that patients with peAF unresponsive to ablation display higher ECG and intraca ...

2020

Cylindrical Dielectric Elastomer Actuator for Cardiac Assist Device

Jonathan André Jean-Marie Chavanne

This work has been triggered because of the need for a new way to relieve the heart. Current solutions are based on invasive systems. The main problem of such assistance is infectious risks. State of the art to define an alternative has allowed highlightin ...

EPFL2019

A Novel Short-term Event Extraction Algorithm for Biomedical Signals

Jean-Marc Vesin, Sasan Yazdani, Sibylle Fallet

In this paper we propose a fast novel non-linear filtering method named Relative-Energy (Rel-En), for robust short-term event extraction from biomedical signals. We developed an algorithm that extracts short- and long-term energies in a signal and provides ...

2018

A modular low-complexity ECG delineation algorithm for real-time embedded systems

David Atienza Alonso, Francisco Javier Rincon Vallejos

This work presents a new modular and lowcomplexity algorithm for the delineation of the different ECG waves (QRS, P and T peaks, onsets and end). Involving a reduced number of operations per second and having a small memory footprint, this algorithm is int ...

2018

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Alfio Quarteroni, Luca Dede', Antonello Gerbi

In this paper, we propose a monolithic algorithm for the numerical solution of the electromechanics model of the left ventricle in the human heart. Our coupled model integrates the monodomain equation with the Bueno-Orovio minimal model for electrophysiolo ...

2018

Numerical approximation of cardiac electro-fluid-mechanical models : coupling strategies for large-scale simulation

Antonello Gerbi

The mathematical modeling of the heart involves several challenges, which are intrinsically related to the complexity of its function. A satisfactory cardiac model must be able to describe a wide range of different processes, such as the evolution of the t ...

EPFL2018

A Patient-Specific Methodology for Prediction of Paroxysmal Atrial Fibrillation Onset

David Atienza Alonso, Jean-Marc Vesin, Amir Aminifar, Sasan Yazdani, Adrian Luca, Elisabetta De Giovanni

In spite of the progress in management of Atrial Fibrillation (AF), this arrhythmia is one of the major causes of stroke and heart failure. The progression of this pathology from a silent paroxysmal form (PAF) into a sustained AF can be prevented by predic ...

2017

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Nikolaos Stergiopoulos, Orestis Vardoulis, Davide Piccini

In this study, an image-based morphometry toolset quantifying geometric descriptors of the left ventricle, aorta and their coupling is applied to investigate whether morphological information can differentiate between subjects affected by diastolic dysfunc ...

Elsevier2017

Complex blood flow patterns in an idealized left ventricle: A numerical study

Alfio Quarteroni, Anna Tagliabue

In this paper, we study the blood flow dynamics in a three-dimensional (3D) idealized left ventricle of the human heart whose deformation is driven by muscle contraction and relaxation in coordination with the action of the mitral and aortic valves. We pro ...

American Institute of Physics2017

Usefulness of P-Wave Duration and Morphologic Variability to Identify Patients Prone to Paroxysmal Atrial Fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Sasan Yazdani, Adrian Luca

Few data are available on the assessment of P-wave beat-to-beat morphology variability and its ability to identify patients prone to paroxysmal atrial fibrillation (AF) occurrence. Aim of this study was to determine whether electrocardiographic (ECG) param ...

Excerpta Medica Inc-Elsevier Science Inc2017