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Concept

Bone resorption

Related publications (22)

Prevention of micromotion-related periprosthetic bone loss using local release of bisphosphonate : theoretical developments and experimental validations

Vincent Stadelmann

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant's long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

EPFL2008

Notch Inhibits Osteoblast Differentiation And Causes Osteopenia

Freddy Radtke

Notch receptors are determinants of cell fate decisions. To define the role of Notch in the adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD) under the control of the type I collagen promoter. First generation ...

2008