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Related lectures (32)

Preclinical Animal Models: Selection & Rationale Log in to Mediaspace to watch this video

Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.

Interrogating SAR: Medicinal Chemistry Log in to Mediaspace to watch this video

Covers medicinal chemistry basics, high-throughput screening, lead discovery milestones, and compound selectivity in drug optimization.

Preclinical Animal Models: Selection & Rationale Log in to Mediaspace to watch this video

Explores the selection and rationale behind preclinical animal models in drug discovery, emphasizing understanding mechanisms of action and domain specificity.

Identifying Correct Target in Medical Chemistry Log in to Mediaspace to watch this video

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Pharmacokinetic & Pharmacodynamic Evaluations Log in to Mediaspace to watch this video

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Pharmacokinetic & Pharmacodynamic Studies Log in to Mediaspace to watch this video

Discusses the importance of assessing PK/PD relationships in drug development and the use of multiple PD biomarkers.

Antiviral Drugs: Mechanisms and History Log in to Mediaspace to watch this video

Delves into the mechanisms and history of antiviral drugs, from targeting viral proteins to the latest COVID-19 treatment.

Inhibitor Design & Analysis Log in to Mediaspace to watch this video

Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.

Inhibitor Design & Analyses Log in to Mediaspace to watch this video

Explores inhibitor design principles, covalent bond formation, and experimental drug development considerations.

Fragment-Based Drug Discovery: Concepts & Technologies Log in to Mediaspace to watch this video

Covers the concepts and technologies of fragment-based drug discovery, exploring hit identification, lead optimization, and screening methods.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.

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