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Concept

Selectable marker

Related publications (8)

Sustained Sleep Fragmentation Induces Sleep Homeostasis in Mice

Pierre Magistretti, Maxime Olivier Baud

Study Objectives: Sleep fragmentation (SF) is an integral feature of sleep apnea and other prevalent sleep disorders. Although the effect of repetitive arousals on cognitive performance is well documented, the effects of long-term SF on electroencephalogra ...

American Academy of Sleep Medicine2015

Transcriptomic characterization of the enzymatic antioxidants FeSOD, MnSOD, APX and KatG in the dinoflagellate genus Symbiodinium

Thomas Krüger

Background The diversity of the symbiotic dinoflagellate Symbiodinium sp., as assessed by genetic markers, is well established. To what extent this diversity is reflected on the amino acid level of functional genes such as enzymatic antioxidants that play ...

BioMed Central2015

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Orbicia Riccio Wicht

Early-life stress is a critical risk factor for developing psychopathological alterations later in life. This early adverse environment has been modeled in rats by exposure to stress during the peripubertal period-that is, corresponding to childhood and pu ...

Nature Publishing Group2014

MAR Elements and Transposons for Improved Transgene Integration and Expression

Nicolas Mermod

Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. In this context, transposons represent attractive gene transf ...

2013

TransFLP - A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination

Melanie Blokesch

Several methods are available to manipulate bacterial chromosomes(1-3). Most of these protocols rely on the insertion of conditionally replicative plasmids (e.g. harboring pir-dependent or temperature-sensitive replicons(1,2)). These plasmids are integrate ...

2012

Neuron-glia metabolic coupling and plasticity

Pierre Magistretti

The focus of the current research projects in my laboratory revolves around the question of metabolic plasticity of neuron-glia coupling. Our hypothesis is that behavioural conditions, such as for example learning or the sleep-wake cycle, in which synaptic ...

Wiley-Blackwell2011

Biogeography, Evolution and Diversity of Free-Living Protists : Insights from Testate Amoebae

Although widely recognized as essential actors of ecosystem processes and representing a significant part of the Earth's biodiversity, free-living protists are poorly known. Major questions concerning their diversity, ecology, and evolution remain complete ...

EPFL2010

Selecting control genes for RT-QPCR using public microarray data

Darlene Goldstein, Mauro Delorenzi, Vlad Popovici

Background: Gene expression analysis has emerged as a major biological research area, with real-time quantitative reverse transcription PCR (RT-QPCR) being one of the most accurate and widely used techniques for expression profiling of selected genes. In o ...

2009